Xaiv ibfisetin hmoov tsumfeem ntau pib nrog peb cov ntsiab lus: purity, nqe thiab xa khoom. Ntawm Botanical Cube, peb pab cov neeg yuav khoom ua haujlwm los ntawm cov lus nug tom qab cov ntsiab lus ua ntej cog lus rau ib qho kev txiav txim ntau. Ib tug formulator xav tau ib tug hmoov uas ua hauj lwm nyob rau hauv cov khoom. Pab neeg zoo xav tau cov txiaj ntsig nws tuaj yeem tshawb xyuas. Peb lub luag haujlwm yog txhawm rau txuas cov kev xav tau kom cov khoom koj pom zoo kom meej meej.Peb cov lus qhia yog xaiv tus neeg muag khoom fisetin uas nws cov lus qhia, cov txiaj ntsig kev xeem, daim ntawv thov qauv thiab kev cog lus cog lus pom zoo nrog ib leeg. Qhov ntawd muab kev yuav khoom, kev tsim qauv thiab pab pawg ua haujlwm zoo sib koom ua ke rau kev pom zoo kev txiav txim.
Pib nrog cov khoom koj npaj ua
Peb thawj qhov kev sib tham yog hais txog dab tsi cov khoom xyaw yuav tsum ua. Rau ib lub tshuaj ntsiav, qhov ntawd yuav txhais tau tias haum cov ntsiab lus rau hauv qhov chaw muaj. Rau cov pos hniav lossis cov kua dej, nws yuav txhais tau tias tuav cov txheej txheem tsim khoom thiab tseem sib xws nrog cov qauv.
Peb qhov ntau muaj xws li tus qauv10%, 50% thiab 98% fisetin los ntawmCotinus coggygria, tseem hu ua smoketree, ntxiv rau cov khoom sib cais dej-soluble 10%.[1] Peb pib nrog daim ntawv thov vim qhov feem pua siab tshaj plaws tsis tuaj yeem daws txhua qhov teeb meem ntawm kev tsim. Botanical Cube
Peb kuj tham txog qhov ua kom tiav, nrog rau cov nqa khoom lossis lwm cov khoom xyaw ntxiv. Koj pab neeg yuav tsum paub tias dab tsi ua rau cov hmoov seem thaum xam cov mis thiab npaj cov lus tshaj tawm.
Lub khw muag khoom muaj nyob hauv qhov kev sib tham no thiab. Piv txwv li, European Commission piav qhia txog nws Novel Food Status Catalog li uas tsis yog kev khi thiab tsis yog tag nrho. Peb kho nws raws li qhov pib ntawm kev tshuaj xyuas cov khoom muaj thiab npaj siv, nrog rau cov kev xav tau thiab cov lus qhia los ntawm cov cai muaj feem xyuam.[2] Yuav pib, qhia peb koj cov khoom hom, lub teb chaws lo lus uas peb, lub hom phiaj specification thiab sim kom muaj nuj nqis. Yog tias qib tseem tsis tau txiav txim siab, piav qhia txog qhov teeb meem koj yuav tsum tau daws. Qhov chaw txwv capsule thiab cov kua mis nrog sediment yog cov ntsiab lus pib sib txawv.
Txheeb xyuas cov ntsiab lus Fisetin ua ntej sib piv cov neeg muab khoom
1. Nkag siab txog HPLC Assay
Peb txhawb kom cov neeg yuav khoom nug ib lo lus nug ntxov: "Puas yog qhov feem pua ntawm cov ntsiab lus fisetin ntsuas los ntawm qhov hnyav, lossis qhov tshwm sim ntawm HPLC peak-cheeb tsam?" HPLC stands rau high-performance kua chromatography, ib tug laboratory txheej txheem siv los cais thiab ntsuas cov tebchaw. Txawm li cas los xij, "kuaj los ntawm HPLC" tsis qhia koj txhua yam txog qhov feem pua tau tshaj tawm.
Peb piav qhia qhov txawv li no:
Peak-cheeb tsam feem pua piav qhia ntau npaum li cas ntawm cov lus teb suav nrog los ntawm fisetin peak.External-standard assay siv tus cwj pwm fisetin siv tus qauv thiab ib qho kev xam xam los txiav txim cov ntsiab lus.
Ib qho txiaj ntsig ntawm thaj chaw yuav tsum tsis txhob cia li nyeem raws li tib feem pua ntawm fisetin los ntawm qhov hnyav.Qhov no tseem ceeb hauv kev ua lag luam tam sim no. Ib tus neeg muag khoom lag luam teev qhov purity yam tsawg kawg nkaus ntawm 98% los ntawm HPLC cheeb tsam nrog rau qhov kev ntsuam xyuas yam tsawg kawg nkaus ntawm 85% los ntawm lwm tus qauv HPLC.[3]Peb siv qhov piv txwv no los qhia tias vim li cas ob feem pua hais txog qhov sib txawv; nws tsis yog, ntawm nws tus kheej, pov thawj tias qhov tshwm sim yog cuav. Ua ntej sib piv cov lus hais, peb xav kom txoj kev tshuaj ntsuam xyuas, siv tus qauv thiab qhia hauv paus kom meej. "As-yog" txhais tau tias cov khoom raws li tau txais; ib tug qhuav-raws li tshwm sim adjusts rau ya raws. Qhov txawv ntawd kuj yuav tsum tau to taub thaum xam cov hmoov ntau npaum li cas los yuav.
2. Txuas qhov tshwm sim mus rau ib pawg uas qhia tau
Peb luam tawm cov ntaub ntawv pov thawj COA-daim ntawv pov thawj ntawm kev tsom xam-rau batch BCI251105Q98, tshaj tawm 98.04% los ntawm HPLC, 0.4% noo noo thiab 0.02% tshauv.[1]
Qhov kev siv no qhia tau hais tias cov ntsiab lus muaj rau kev tshuaj xyuas, tab sis tus excerpt ib leeg tsis tsim ib qho kev ntsuam xyuas sab nraud. Ua ntej koj pom zoo ib qho kev txiav txim, nug peb rau cov ntaub ntawv batch sib txuam thiab kev pom zoo ntawm lub hauv paus ntawm kev xam.Koj pab neeg zoo yuav tsum tuaj yeem txuas cov khoom npe, qib, tus lej qauv thiab cov txiaj ntsig tsis suav nrog. Yog tias lub chaw kuaj mob tau txais cov txiaj ntsig sib txawv, thawj kauj ruam yog los sib piv cov qauv ntawm tus kheej, kev npaj, siv tus qauv thiab qhia hauv paus. Qhov sib txawv tsis tau piav qhia xav tau kev daws teeb meem ua ntej kev pom zoo.
Tshawb xyuas cov ntaub ntawv xa khoom thiab chaw tsim khoom
Peb cia siab tias cov neeg siv khoom yuav nug qhov twg lawv cov fisetin raug tsim thiab leej twg yog lub luag haujlwm rau kev tso tawm zoo. Lub tuam txhab noj qhov kev txiav txim, chaw tsim khoom thiab chaw kuaj sim yuav muaj lub luag haujlwm sib txawv; cov luag hauj lwm yuav tsum tau meej nyob rau hauv tus neeg muag khoom tshuaj xyuas.Rau botanical traceability, peb xav kom koj thov lub scientific nroj tsuag npe, cog ib feem thiab kev twb kev txuas ntawm cov khoom pib thiab cov tiav batch. Ib tus neeg muag khoom yuav tsum tuaj yeem piav qhia nws txoj hauv kev tsim khoom raws li koj pab neeg zoo tuaj yeem soj ntsuam.
Peb cov ntaub ntawv fisetin luam tawm suav nrog Cotinus ua cov duab, cov duab hauv lub Hoobkas, cov ntaub ntawv siv COA thiab HPLC. Kev soj ntsuam ywj pheej los ntawm cov chaw soj nstuam xws li SGS lossis Eurofins kuj tuaj yeem tham txog, nrog rau cov peev txheej, tus nqi thiab sijhawm pom zoo rau qhov project.[1]Thaum koj thov pob ntawv tsim nyog los ntawm peb, cov ntaub ntawv no ua haujlwm sib txawv:
| Cov ntaub ntawv | Qhov Yuav Tsum Qhia Koj Pab Pawg |
|---|---|
| Khoom specification | Cov kev xav tau pom zoo rau cov khoom siv |
| Batch COA | Cov txiaj ntsig rau ib qho kev txheeb xyuas ntau lawm |
| Independent Laboratory Report | Qhov kev ntsuam xyuas tau ua rau ntawm tus qauv uas tau txheeb xyuas |
| Daim ntawv pov thawj ntawm qhov chaw lossis kev tswj hwm-system | Lub tuam txhab them nyiaj, qhov chaw, kev ua ub no thiab lub sijhawm siv tau |
| Daim ntawv qhia kev nyab xeeb | Kev tuav, khaws cia thiab cov ntaub ntawv kev nyab xeeb ntawm chaw ua haujlwm |
Rau qhov yuav tsum tau muaj ntawv pov thawj, qhia peb seb tus qauv twg koj tus neeg muag khoom pom zoo cov txheej txheem xav tau. Txheeb xyuas tus tuav daim ntawv pov thawj tam sim no, qhov chaw tsim khoom thiab thaj chaw. Ib daim ntawv qhia txog kev kuaj mob xav tau nws tus kheej tus kheej tus kheej thiab kuaj vaj huam sib luag; lub npe kuaj ib leeg tsis tsim kom muaj kev ua raws cai.
Rau cov kab mob sib kis, peb pom zoo qhov yuav tsum tau muaj qhov seem-kua, hnyav-hlau thiab microbiological txwv, ntxiv rau lwm qhov kev ntsuas seem ntxiv uas xav tau rau qhov project. "Tsis pom" yuav muaj txiaj ntsig thaum qhov kev txwv tsis pub tshaj tawm.
Rau kev tsim khoom noj khoom haus hauv Teb Chaws Asmeskas, FDA kev taw qhia piav qhia txog cov xwm txheej rau kev cia siab rau COA tus neeg muag khoom, suav nrog cov khoom tsim nyog thiab kev lees paub raws sijhawm. Kev ntsuam xyuas tus kheej cov khoom noj muaj nws tus kheej tshwj tsis yog FDA pom zoo rau kev zam.[4] Qhia rau peb paub lub vaj huam sib luag uas yuav tsum tau ua ua ntej ua piv txwv yog li kev sim ntxiv, lub sijhawm thiab tus nqi tuaj yeem pom zoo ntxov.
Ntsuam xyuas tus neeg sawv cev qauv hauv koj cov qauv
Ua ntej xa, peb xav pom zoo tias tus qauv yuav tsum ua kom pom thiab sau nws qib, muaj pes tsawg leeg thiab batch tooj. Kuj tseem tsim tau seb nws yog los ntawm cov khoom lag luam muaj los yog kev tsim kho batch.Rau qhov project capsule, uas yuav txhais tau tias xyuas seb cov hmoov sib tov li cas, ntws thiab ntim. Rau cov gummy, nws yuav txhais tau tias kuaj xyuas kev faib tawm, tsos thiab cov ntsiab lus tom qab ua tiav. Rau cov kua los yog tawv nqaij daim tawv nqaij, nws yuav cuam tshuam nrog kev tawg, nag lossis daus thiab ruaj khov hauv qhov tseeb.
Rau txhua qhov kev sim, pom zoo cov txheej txheem dhau los nrog koj cov qauv tsim thiab pab pawg zoo. Ib qho kev sib piv meej xav tau tib lub qauv, kev thauj khoom thiab kev xeem rau txhua tus neeg sib tw. Peb tuaj yeem sib tham txog tus qauv tsim nyog thaum paub txog cov kev xav tau ntawm kev sim.
1. Txhais qhov kev sim ua tiav zoo li cas
Rau qhov pib ua kua-formulation npo, ib qho piv txwv txoj kev npaj yog sau cov kev sib xyaw, pH, tsos thiab sediment tam sim ntawd tom qab kev npaj thiab tom qab 24 teev. Kev ntsuam xyuas cov ntsiab lus thiab kev ruaj ntseg ntev dua kuj tseem yuav tsim nyog. Lub npov pom luv luv teb cov lus nug txog kev sib haum xeeb thawj zaug.
Rau cov tshuaj ntsiav, ib qho kev sim muaj txiaj ntsig tuaj yeem sau cov ntaub ntawv sib xyaw ua ke thiab ua tiav kev ua haujlwm ntawm cov khoom siv npaj thauj khoom. Cov pov thawj ntawd pab koj pab neeg txiav txim siab seb qib twg tuaj yeem mus rau qhov kev sim ntau lawm.Peb kuj paub qhov txawv ntawm cov ntsiab lus ntsuas. Ib daim duab tuaj yeem pom cov av qeeg lossis xim hloov. Nws tsis tuaj yeem tsim ntau npaum li cas fisetin tseem nyob.
2. Siv cov ntaub ntawv ruaj ntseg rau kev txiav txim siab
Peb siv qhov kev sim luam tawm los piav qhia vim li cas qhov kev sim ntsuas tseem ceeb. Wang thiab Zhao tau sim kwv yees li 30 micromolar fisetin hauv 100 millimolar phosphate buffers npaj los ntawm DMSO / ethanol stocks, siv spectroscopic ntsuas hauv triplicate. Ntawm 37 degree, qhov degradation tus nqi tas li yog 0.00830 ± 0.00045 ib teev ntawm pH 6.0, piv rau 0.202 ± 0.014 ntawm pH 7.5. Cov no txhais tau tias ± tus qauv sib txawv qhia txog kwv yees li 24-fold sib txawv; tus nqi siab dua qhov tsis tu ncua txhais tau tias poob ntawm fisetin sai dua nyob rau hauv kev sim ntsuas.[5] Qhov no ua rau peb muaj laj thawj los tham txog pH thaum ntsuas tus qauv. Nws tsis kwv yees qhov khoom tiav lub txee lub neej. Rau kev yuav khoom, nug seb cov pov thawj kev ruaj ntseg twg muaj rau qib pes tsawg, ntim khoom thiab chaw cia khoom uas koj npaj yuav siv.
Sib piv cov nqi raws li koj qhov Specification
Thaum cov khoom siv thiab kev sim ua kom pom tseeb, peb tuaj yeem muaj kev sib tham txog tus nqi ntau dua.Nqe ib kilogram tseem ceeb, tab sis qhov ntau ntawm cov hmoov yuav tsum tau ua kom tau raws li lub hom phiaj tseem ceeb heev. Yog li ua kev sim, freight, ntim thiab cov khoom muag.
1. Sib piv cov hmoov kom muaj nuj nqis uas koj qhov project xav tau
Xav txog ib txoj kev npaj tsim tawm uas xav tau 10 kg ntawm cov tshuaj fisetin. Xav tias peb cov hmoov tau txheeb xyuas, sib piv ncaj qha li-yog qhov kev soj ntsuam loj ntawm 10%, 50% thiab 98%, tsis muaj kev ua haujlwm poob.
| Txheeb xyuas Fisetin Mass Assay | Kev suav | Yuav tsum muaj hmoov |
|---|---|---|
| 10% | 10 kg ÷ 0.10 | 100.00 kg |
| 50% | 10 kg ÷ 0.50 | 20.00 kg |
| 98% | 10 kg ÷ 0.98 | Kwv yees li 10.20 kg |
Peb siv qhov no los ua ib qho piv txwv suav, tsis yog cov neeg siv khoom lossis cov lus hais txog qhov kev ntsuam xyuas ntawm txhua qib uas tau tshaj tawm. Txhawm rau sib piv cov lus hais tiag tiag, muab cov hmoov hmoov ntau ntxiv los ntawm nws tus nqi thiab ntxiv cov nqi yuav khoom.
Lwm cov khoom xyaw thiab kev ua haujlwm ntawm lub cev tseem tseem ceeb. Cov ntsiab lus qis dua tuaj yeem haum rau ib qho kev sib xyaw, thaum cov khoom siv ntau dua tuaj yeem pab thaum tsim qhov chaw tsawg. Peb ua qhov kev txiav txim siab tawm tsam cov khoom luv luv.Our coj mus muag tshuaj xyuas kuj tseem suav nrog qhov kev txiav txim yam tsawg kawg nkaus, pob loj, cov nqi kuaj ntxiv, cov nqe lus xa khoom thiab cov nyiaj them poob haujlwm. Cov ntsiab lus meej ua rau cov kev sib tw tau yooj yim dua los sib piv thiab txo qhov xav tsis thoob tom qab pom zoo.
Pom zoo rau qhov Kev Txiav Txim Loj Tshaj Tawm Cov Qauv Yuav Tsum Tau
Thaum koj pab neeg pom zoo cov qauv, peb xav kom muab cov kev lees paub rau hauv kev yuav khoom specification. Qhov no muab qhov kev txiav txim coj mus muag kom pom tseeb qhov kev lees paub.Sau qhov muaj pes tsawg leeg, kev soj ntsuam txoj kev, qhia hauv paus thiab txwv tsis pub muaj paug, ua ke nrog qhov loj me, qhov ntom ntom lossis cov tsos mob uas cuam tshuam rau koj cov txheej txheem. Khaws cov qauv kev pom zoo nrog cov kev qhia tshwj xeeb.Cov khoom xa tuaj tuaj yeem tuaj ntawm cov khoom sib txawv. Nyob rau hauv tas li ntawd, tshuaj xyuas qhov tso tawm COA rau cov tshiab batch tiv thaiv qhov pom zoo specification. Cov ntawv xa khoom xa tuaj thiab cov ntaub ntawv yuav tsum txheeb xyuas tib yam khoom xa tuaj. Rau kev rov muab khoom dua, nug txog cov txiaj ntsig muaj nyob hauv ntau pawg siv cov kev sib piv.
Peb kuj tham txog kev hloov pauv nrog cov neeg siv khoom:
uas hloov mus rau qhov chaw, qhov chaw, muaj pes tsawg leeg, txheej txheem los yog xeem txoj kev xav tau kev ceeb toom, thiab thaum xav tau ib tug tshiab qauv. Cov nqe lus no yuav tsum tau pom zoo ua ntej kev txiav txim rov pib dua. Cov lus cog tseg rau kev xa khoom xav tau cov ntsiab lus zoo sib xws. "Nyob rau hauv Tshuag" yuav tsum coj mus rau kev sib tham txog qib xaiv, muaj kom muaj nuj nqis, batch tso tawm raws li txoj cai thiab cov ntaub ntawv xav tau. Peb cais lub sijhawm xav tau rau kev tsim khoom, kuaj thiab thauj thaum npaj kev txiav txim.
Lub neej txee tseem tshuav thaum tuaj txog kuj tsim nyog tau txais kev saib xyuas, tshwj xeeb tshaj yog thaum cov hmoov yuav raug siv thoob plaws ntau qhov kev tsim khoom.Ua ntej thawj qhov kev txiav txim, pom zoo li cas qhov sib txawv ntawm cov khoom tuaj yuav raug tshawb xyuas. Txheeb xyuas cov qauv khaws cia, cov txheej txheem tshuaj ntsuam xyuas thiab, yog tias tsim nyog, lub chaw kuaj mob ywj pheej lees txais rau ob tog. Cov nqe lus txiav txim yuav tsum tau hais txog cov lus teb yog tias cov khoom ua tsis tau raws li qhov kev pom zoo.Our txoj cai txiav txim siab yog ncaj nraim: daws cov lus nug ntawm tus kheej thiab tshuaj xyuas ua ntej, paub meej tias daim ntawv thov tsim nyog, tom qab ntawd sib piv cov khoom xa tuaj thiab tag nrho cov nqi ntawm cov neeg xa khoom uas ua tau raws li cov kev xav tau. Tus nqi qis tsis tuaj yeem daws cov lus nug tsis zoo.
Thov ib tug Fisetin Sample thiab Specification ntawm Botanical Cube
Koj tuaj yeem pib nrog ib qho kev thov tshwj xeeb: "Thov pab peb sib piv cov qib fisetin haum thiab lees paub cov ntaub ntawv xav tau rau peb mus sib hais." Peb tuaj yeem hais koj qhov project hauv peb theem. Ua ntej, txhais cov khoom siv. Xa koj daim ntawv thov, qhov chaw ua lag luam, lub hom phiaj fisetin cov ntsiab lus thiab txhua yam kev txwv tsis pub muaj. Peb tuaj yeem sib tham txog qhov tsim nyog specification thiab qhia meej lub hauv paus kev xeem ua ntej koj xaiv tus qauv.Tom ntej no, npaj qhov kev ntsuam xyuas. Thov qhov kev qhia tshwj xeeb tam sim no, cuam tshuam COA, muaj cov ntaub ntawv tshuaj ntsuam xyuas thiab lwm yam kev sim ntxiv uas koj pab neeg ua haujlwm xav tau. Peb cov qauv luam tawm yog 10-50 g; paub meej qhov ntau, muaj thiab freight rau koj mus sib hais.[1]
Tom qab ntawd, npaj khoom. Qhia koj tus neeg tsav tsheb kom muaj nuj nqis, xav tau rov qab xav tau, ntim khoom thiab hnub tuaj txog. Peb tuaj yeem sib tham txog kev hais lus thiab kev xa khoom rau qhov kev xav tau ntawd. Rau kev cai formulations los yogOEM/ODMtej yaam num, suav nrog cov hom khoom npaj thiab kev loj hlob luv luv. Emailsales@botanicalcube.comnrog lub ntsiab lus"Fisetin Sample thiab Specification Thov."Koj tseem tuaj yeem tshuaj xyuas peb cov ntaub ntawv fisetin hmoov ntau.Peb ua haujlwm nrog cov khoom lag luam, cov neeg xa khoom, cov npe ntxiv thiab cov tuam txhab cog lus. Yog tias koj twb muaj qhov kev yuav khoom tshwj xeeb lossis daim ntawv nug tus neeg muag khoom, xa mus rau koj qhov kev nug kom peb tuaj yeem hais txog cov kev xav tau uas tseem ceeb rau koj pab neeg.
Cov ntaub ntawv
[1] Botanical Cube Inc.Bulk Fisetin Powder Supplier: 10%, 50% thiab 98% HPLC Qib.Specifications, reference batch COA, kev tsim nyog thiab cov ntaub ntawv coj mus kuaj. Cov ntaub ntawv khoom. Tau txais Lub Kaum Ib Hlis 5, 2026.
[2] European Commission.Novel Food Status Catalogue.Catalog kev taw qhia thiab kev txwv. Tau txais Lub Kaum Ib Hlis 5, 2026.
[3] Brilliance Khoom noj khoom haus.Fisetin.Kev lag luam specification paub qhov txawv ntawm HPLC-cheeb tsam purity los ntawm kev soj ntsuam sab nraud. Tshaj tawm specification. Tau txais Lub Kaum Ib Hlis 5, 2026.
[4] US Food and Drug Administration.Daim Ntawv Qhia Txog Kev Ua Raws Cai Me Me: Tam sim no Kev Ua Haujlwm Zoo Tshaj Plaws hauv Kev Tsim Khoom, ntim, sau npe, lossis tuav haujlwm rau kev noj zaub mov ntxiv.Kev taw qhia txog 21 CFR 111.75, tus neeg tsim khoom tsim nyog thiab kuaj tus kheej. FDA qhia.
[5] Wang, J., Zhao, X.H. (2016). Degradation kinetics ntawm fisetin thiab quercetin nyob rau hauv cov kev daws cuam tshuam los ntawm nruab nrab pH, kub thiab co-existing proteins.Phau ntawv Journal ntawm Serbian Chemical Society, 81(3), 243–253. doi: 10.2298/JSC150706092W.