Icariin yog lub ntuj tsim muaj nyob rau hauv ntau yam tshuaj suav suav uas tau txais koob meej raws li kev ntxiv. Extracted los ntawm cov nroj tsuag zoo li Epimediumsagittatum (horny tshis nroj), icariin tau pom tias muaj ntau yam txiaj ntsig kev noj qab haus huv. Hauv tsab xov xwm no, peb yuav tshawb xyuas seb icariin yog dab tsi, nws cov kev siv ib txwm siv, cov txheej txheem ntawm kev ua, thiab cov kev siv tshuaj kho tau zoo.
Txhais Icariin
Icariin (C33H40O15) yog prenylated flavonol glycoside thiab thawj bioactive tivthaiv ntawm tshuaj ntsuab hauv tsev neeg Epimedium. Nws tau raug cais tawm thawj zaug hauv xyoo 1980 los ntawm E. sagittatum, tab sis ntau hom xws li E. brevicornum thiab E. koreanum kuj muaj icariin.
Chemically, icariin muaj cov flavonoid kaempferol nrog ntxiv prenyl thiab glycoside pawg. Cov qauv tshwj xeeb no tso cai rau icariin nkag mus rau hauv hlwb ntau dua thiab ua rau muaj kev cuam tshuam hauv lub cev piv rau lwm cov flavonoids.
Icariin tau pom tias siv ntau yam tshuaj siv tshuaj, suav nrog:
- PDE5 enzyme inhibition
- Nitric oxide ntau lawm stimulation
- Estrogen receptor agonism
- Androgen receptor agonism
- Nerve growth factor induction
Los ntawm cov txheej txheem no, icariin tuav cov lus cog tseg rau kev kho erectile kawg, kev txawj ntse poob, pob txha pob txha, infertility, thiab ntau dua. Ua ntej, cia peb saib cov kev siv ib txwm siv ntawm no intriguing compound.
Tsoos tshuaj siv ntawm Icariin
Nroj tsuag los ntawm Epimedium genus muaj keeb kwm dav dav hauv cov tshuaj suav tshuaj rau:
- Kho kev sib deev dysfunction thiab infertility
- Alleviating pob qij txha thiab osteoarthritis
- Boosting raum noj qab haus huv thiab stemming nkees
- Txhim kho kev txawj ntse thiab kev nco
- Restoring tag nrho cov tseem ceeb thiab kev noj qab nyob zoo
Kev siv Epimedium suav nrog kho impotence, tso zis ntau zaus, tsis muaj zog ntawm cov ceg, tsis nco qab, thiab qaug zog hauv cov neeg laus. Feem ntau ntawm cov kws tshuaj ntawm Epimedium cov nroj tsuag raug ntaus nqi rau icariin hmoov.
Cov kev tshawb fawb niaj hnub no txij li tau lees paub ntau yam ntawm cov kev siv ib txwm muaj. Ob qhov cuam tshuam loj ntawm icariin nrog kev txhawb nqa kev tshawb fawb tseem ceeb yog txhim kho kev sib deev thiab kev paub txog kev ua haujlwm.
Icariin rau Kev Sib Deev Kev Noj Qab Haus Huv thiab Kev Ua Haujlwm
Kev tshawb fawb dav dav qhia txog icariin's aphrodisiac zoo thiab kev ua tau zoo rau kev kho erectile kawg. Mechanisms muaj xws li:
- Ua kom muaj nitric oxide ntau ntxiv uas ua rau cov hlab ntsha ntawm tes
- inhibiting PDE5 enzymes uas rhuav tshem cGMP signaling
- Mimicking testosterone thiab stimulating cov ntaub so ntswg kev loj hlob
Qhov no ua rau muaj ntshav ntau ntxiv thiab kev ua haujlwm androgen tseem ceeb rau kev sib deev arousal thiab kev ua haujlwm.
Tib neeg kev sim qhia txhua hnub ntxiv nrog Epimedium extracts hmoov uas muaj icariin ua rau muaj kev txhim kho erectile kawg thiab kev sib deev kev nyab xeeb yam tsis muaj kev phiv loj. Cov txiaj ntsig zoo li zoo tshaj plaws hauv cov neeg mob me me mus rau nruab nrab ED.
Rau kev txhim kho kev sib deev, koob tshuaj icariin ntawm 3-15 mg ib kilogram ntawm lub cev hnyav tshwm sim raws li cov pov thawj kho mob. Icariin's pro-circulatory teebmeem kuj tseem tuaj yeem txhim kho poj niam kev sib deev los ntawm kev ua kom cov ntshav khiav hauv qhov chaw mos.
Kev paub txog kev txawj ntse thiab cov txiaj ntsig Neuroprotective
Lwm qhov tseem ceeb ntawm kev siv icariin yog tiv thaiv hnub nyoog txog kev paub txog kev poob qis thiab kab mob neurodegenerative. Kev soj ntsuam neuroprotective mechanisms suav nrog:
- Txhawb kev loj hlob ntawm neurite thiab synapse tsim
- Txo cov pob txha ntawm amyloid beta plaques
- Kev nce qib acetylcholine hauv lub hlwb
- Tiv thaiv tawm tsam neuronal apoptosis thiab toxicity
Qhov no neuroactivity prompts ntxiv tsim kev kawm, nco, chaw, thiab puas siab puas ntsws lucidity - tshwj xeeb tshaj yog nyob rau hauv tsiaj qauv ntawm Alzheimer tus mob. Energizer zoo li cuam tshuam kuj tau piav qhia.
Rau kev paub txog cov txiaj ntsig, qis dua icariin koob tshuaj ntawm 1-5 mg/kg BW zoo li muaj txiaj ntsig thiab ua pov thawj ntxiv rau tib neeg txoj kev tshawb fawb. Icariin lub peev xwm los ua cov teebmeem neurotrophin qhia tau hais tias kev cog lus tshwj xeeb rau cov mob neurodegenerative.
Optimizing raum Health nrog Icariin
Raws li tau hais ua ntej, icariin muaj cov ntawv thov rau lub raum kom muaj zog ib yam nkaus. Cov kev tshawb fawb niaj hnub no qhia tias nws yuav pab tau rau lub raum noj qab haus huv los ntawm ntau lub tswv yim:
- Txo lub raum mob los ntawm inhibiting NF-kB thiab NLRP3
- Tiv thaiv glomerular endothelial hlwb los ntawm kev puas tsuaj rau cov piam thaj ntau
- Ua kom qeeb ntawm kev mob ntshav qab zib nephropathy
- Tiv thaiv lub raum fibrosis txuam nrog raum kab mob
- Loweringproteinuria thiab txhim kho cov cim pom
Cov koob tshuaj ntawm 5-20 mg/kg BW tau qhia txog kev tiv thaiv lub raum hauv cov nas qauv ntawm cov kab mob raum. Qhov no qhia tau hais tias icariin supplementation tuaj yeem pab tswj lub raum ua haujlwm thiab txo cov ntshav lim ntshav.
Lwm Cov Kev Siv Kho Mob Muaj Peev Xwm
- Cov pob txha noj qab haus huv: Ua kom cov pob txha ceev thiab tiv thaiv osteoporosis hauv cov qauv tsiaj
- Kev noj qab haus huv metabolic: Txhim kho insulin rhiab heev thiab qabzib metabolism hauv cov nas ntshav qab zib
- Kev noj qab haus huv kev laus: kho polycystic zes qe menyuam syndrome hauv nas thiab txhim kho fertility
- Kev tswj kev tiv thaiv kab mob: nthuav tawm cov tshuaj tiv thaiv kab mob piv rau cov tshuaj xws li dexamethasone
- Kev noj qab haus huv ntawm lub plawv: txo qis atherosclerotic plaque tsim hauv vitro
Thaum tseem ua ntej, icariin qhia tau cog lus tias yog tus neeg sawv cev kho mob thoob plaws ntau lub tshuab vim nws cov bioactivity multifaceted. Kev tshawb fawb tsis tu ncua txuas ntxiv nthuav tawm cov ntawv thov kho mob tshiab.
Cov ntsiab lus tseem ceeb rau kev siv Icariin
Thaum feem ntau ua tau zoo, muaj qee qhov kev ceev faj kom nco ntsoov txog icariin supplementation:
- Zam kev xeeb tub lossis pub niam mis kom txog thaum muaj kev nyab xeeb
- Tej zaum yuav cuam tshuam nrog cov tshuaj tiv thaiv ED, antidepressants, anticoagulants
- Cov koob tshuaj zoo tshaj tsis tau tsim, tab sis 10-100 mg txhua hnub yog ntau
- tuaj yeem ua rau xeev siab me ntsis, kiv taub hau, thiab mob taub hau thaum noj ntau heev
- Kev nyab xeeb mus sij hawm ntev tseem tsis paub, yog li kev siv lub voj voog 4 lub lis piam rau, 1 lub lis piam tawm
Rau qhov zoo tshaj plaws, purity, thiab potency, xaiv lub npe nrov npe siv cov txheej txheem Epimedium extracts. Raws li nrog cov tshuaj ntxiv tshiab, pib qis thiab nce koob tshuaj maj mam thaum saib xyuas cov kev mob tshwm sim.
Yav tom ntej Outlook rau Icariin
Nrog rau mounting kev tshawb fawb validating ib txwm siv, cov kev kho mob yav tom ntej zoo li kaj rau icariin. Cov kev txaus siab tshwj xeeb suav nrog kev kho cov kev paub tsis meej, kev sib deev tsis ua haujlwm, osteoporosis, kab mob raum, cov kab mob metabolic thiab cov hlab plawv.
Standardization thiab pharmacological kev txhim kho rau icariin cov tshuaj cov qauv yuav ntxiv zog nws potency thiab. Kuj tseem muaj peev xwm ua ke icariin nrog lwm cov tshuaj ntuj xws li L-citrulline lossis resveratrol kom ua tau zoo dua.
Xaus
Lub prenylated flavonoid icariin qhia tau hais tias muaj txiaj ntsig zoo tshuaj nrog ntau yam kev siv. Extracted ib txwm los ntawm Epimedium cov nroj tsuag, icariin hmoov supplementation yuav pab kom nyab xeeb kho ntau yam mob. Kev kho mob ntxiv ntxiv thiab kev tsim kho tshiab tuaj yeem ua rau icariin yog ib qho cuab yeej tseem ceeb hauv kev ua haujlwm ntawm cov tshuaj armamentarium yav tom ntej.
Hauv kev xaus, icariin, thawj bioactive tivthaiv ntawm tshuaj ntsuab nyob rau hauv Epimedium tsev neeg, muaj ntau yam ntawm cov txiaj ntsig kev noj qab haus huv. Los ntawm kev txhim kho kev sib deev kev noj qab haus huv thiab kev paub txog kev ua haujlwm los txhawb lub raum kev noj qab haus huv, icariin tau pom muaj txiaj ntsig zoo los ntawm nws ntau yam kev ua haujlwm. Yog tias koj xav tau Epimedium Extract nrog ntau qib ntawm Icariin, Botanical Cube Inc. Yog xav paub ntxiv los yog tso ib qho kev txiav txim, thov hu rau peb ntawmsales@botanicalcube.com.
Cov ntaub ntawv:
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Jiang, Z., Hu, B., Wang, J., Tang, Q., Tan, C., Xiao, C., ... & Liang, S. (2021). Herba Epimedii (Yinyanghuo) rau osteoporosis: Kev tshuaj xyuas qhov systematic ntawm kev tshawb fawb txog kev kho mob thiab kho mob.Phytomedicine, 85, 153390.
Sun, YN, Zang, QF, Chen, YF, Wang, JY, Li, R., Li, P., ... & Qin, LP (2016). Icariin nthuav tawm cov nyhuv anti-amyloidogenic los ntawm inhibiting oligomerization ntawm amyloid peptide. Neuropharmacology, 105, 115-123.
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Zhang, Z., & Tong, T. (2014). Kev kho mob muaj peev xwm ntawm icariin rau lub hlwb ischemia thiab kev raug mob reperfusion. Metabolic hlwb kab mob, 29(3), 605-611.
Liu, WJ, Xin, ZC, Xin, H., Yuan, YM, Tian, L., Guo, YL, ... & Liu, GZ (2007). Cov teebmeem ntawm icariin ntawm erectile muaj nuj nqi thiab kev qhia ntawm nitric oxide synthase isoforms nyob rau hauv castrated nas. Asian Journal of andrology, 9(6), 785.
Ning, H., Xin, ZC, Lin, G., Banie, L., Lue, TF, & Lin, CS (2006). Cov teebmeem ntawm icariin ntawm phosphodiesterase-5 kev ua haujlwm hauv vitro thiab cyclic guanosine monophosphate theem hauv cavernous cov leeg nqaij. Urology, 68(6), 1350-1354.
Chen, KM, Ge, BF, & Ma, HP (2007). Icariin, flavonoid los ntawm tshuaj ntsuab Epimedium txhim kho osteogenic sib txawv ntawm nas thawj pob txha pob txha stromal hlwb. Pharmazie, 62(12), 939-942.