Qhov twg zoo dua rau Kev Tiv Thaiv -aging, NAD lossis NMN?

Thaum peb tham nrog peb cov neeg siv khoom thoob ntiaj teb txog kev tiv thaiv- cov khoom xyaw rau hnub no, ib lub ntsiab lus tseem ceeb ntawm qhov kev sib tham: lub zog ntawm tes. Los ntawm peb qhov kev xav, kev laus tsis yog ib txoj hauv kev pom xwb - nws yog qhov tob tob hauv peb cov hlwb tsim thiab siv zog npaum li cas. Lub hauv paus ntawm txoj kev no yogNAD ⁺ (nicotinamide adenine dinucleotide), coenzyme tseem ceeb rau kev ua haujlwm mitochondrial, kho DNA, thiab tswj cov metabolism. Txawm li cas los xij, kev tshawb fawb tau pom tias NAD⁺ qib poob qis nrog hnub nyoog - ntau li 50% ntawm hnub nyoog nruab nrab thiab tom qab lub neej [1]. Qhov kev poob qis no cuam tshuam nrog kev qaug zog, txo qis kev ua haujlwm ntawm metabolic, thiab ua rau muaj kev cuam tshuam ntau ntxiv rau hnub nyoog -txog cov xwm txheej.

Nyob rau tib lub sijhawm, peb tab tom pom kev hloov pauv meej thoob ntiaj teb los tiv thaiv- kev lag luam kev laus. Cov neeg yuav khoom tsis txaus siab rau cov qauv siv dav dav; xwb, lawv tab tom mus rau siab -purity, science-backed raw cov khoom xyaw. Cov ntaub ntawv kev lag luam qhia tau hais tias lub neej ntev thiab kev tiv thaiv- kev laus kev lag luam yuav tsum tshaj $ 120 nphom los ntawm 2030, nrog NAD⁺- cuam tshuam cov tebchaw ua qhov tseem ceeb[2]. Nyob rau hauv cov ntsiab lus no, cov lus nug tshwm sim ib txwm tshwm sim: yuav tsum NAD⁺ tau ntxiv ncaj qha, lossis nws puas zoo dua los tso siab rau nws qhov ua ntej,NMN?

Txhawm rau teb cov lus nug no, peb yuav tsum saib seb cov molecules no coj li cas lom neeg. NAD⁺ nws tus kheej, txawm tias yog lub hom phiaj molecule, nthuav tawm cov kev txwv tsis pub muaj. Nws qhov loj me me me me thiab cov qauv them ua rau nws nyuaj dhau los ntawm cov cell membranes. Thaum noj hauv qhov ncauj, NAD⁺ tseem ua rau muaj kev puas tsuaj hauv plab hnyuv, uas txwv tsis pub nws cov bioavailability. Qhov no yog vim li cas NAD⁺ supplementation feem ntau yog xa los ntawm cov txheej txheem hauv cov hlab ntsha hauv chaw kho mob-ib txoj hauv kev uas tsis yooj yim los yog ntsuas tau rau cov neeg siv khoom.

NMN, ntawm qhov tod tes, muab txoj hauv kev zoo dua. Raws li tus thawj coj ncaj qha rau NAD⁺, NMN yog me dua thiab siv tau yooj yim dua. Ib qho kev ua tiav tseem ceeb tuaj rau xyoo 2019, thaum kev tshawb fawb luam tawm hauv Nature Metabolism tau txheeb xyuas qhov tshwj xeeb thauj cov protein, Slc12a8, uas pab txhawb kev nqus ncaj qha ntawm NMN hauv cov hnyuv. [3]. Qhov kev tshawb pom no tau muab pov thawj muaj zog uas NMN tsis yog bioavailable nkaus xwb tab sis nquag thauj mus rau hauv lub cev.

Thaum nqus tau, NMN tsuas yog xav tau ib kauj ruam enzymatic nkaus xwb-ntawm NMNAT enzymes- kom hloov mus rau NAD⁺. Piv rau lwm txoj hauv kev, xws li cov uas muaj nicotinamide lossis tryptophan, txoj kev no luv luv thiab ua haujlwm tau zoo dua.

Cov ntaub ntawv kho mob ntxiv txhawb qhov txiaj ntsig no. Hauv kev sim tib neeg randomized, kev noj tshuaj txhua hnub nrog 500 mg ntawm NMN ua rau kwv yees li 38% nce hauv cov ntshav NAD⁺ qib hauv plaub lub lis piam, nrog rau qhov siab tshaj plaws tau pom nyob rau hauv ob peb teev tom qab noj. [4]. Cov kev tshawb fawb tsis ntev los no qhia txog koob tshuaj - cov nyhuv nyob ntawm qhov kev noj haus ntau dua tuaj yeem ua rau nce mus txog 60% nyob rau lub sijhawm ntxiv ntxiv[5].

Tshaj li tsuas yog nce qib NAD⁺, NMN kuj tau pom cov txiaj ntsig ua haujlwm thoob plaws ntau lub tshuab. Piv txwv li, kev tshawb fawb nrog rau cov neeg laus tau pom tias muaj kev txhim kho hauv vascular endothelial muaj nuj nqi, nrog rau kev khiav -kev kho kom haum xeeb nce los ntawm 1.4%, qhov taw qhia tseem ceeb ntawm kev noj qab haus huv ntawm cov hlab plawv.[6]. Hauv cov metabolic domain, NMN supplementation tau txuas mus rau kwv yees li 25% kev txhim kho hauv insulin rhiab heev hauv cov leeg pob txha, qhia txog nws lub luag haujlwm hauv lub zog metabolism thiab kev tswj cov piam thaj.[7].

Cov teebmeem no tau txuas nrog rau lub luag haujlwm lom neeg ntawm NAD⁺ nws tus kheej. NAD⁺ yog qhov tseem ceeb rau kev ua haujlwm ntawm cov enzymes xws li PARPs, uas koom nrog hauv DNA kho, thiab sirtuins, uas tswj kev laus -txog txoj hauv kev. Thaum NAD⁺ qib poob qis, qhov ua tau zoo ntawm cov tshuab no raug cuam tshuam, ua kom cov txheej txheem cellular aging.[8]. Los ntawm kev kho cov qib NAD⁺ los ntawm NMN supplementation, cov kev no tuaj yeem ua haujlwm tau zoo dua.

Qhov tseem ceeb, cov ntaub ntawv kev nyab xeeb kuj tau txhawb nqa. Kev sim tib neeg tau tshaj tawm tias NMN tau txais txiaj ntsig zoo ntawm koob tshuaj txog li 1000 mg ib hnub twg, tsis muaj qhov cuam tshuam loj npaum li cas txawm tias siv sijhawm ntev dua -[9]. Rau cov neeg tsim khoom lag luam kev tshaj lij, qhov no muab lub hauv paus muaj zog rau kev txhim kho cov khoom lag luam nrog cov ntaub ntawv muaj txiaj ntsig zoo.

Los ntawm qhov kev xav ntawm kev lag luam, peb kuj tau pom qhov kev hloov pauv ntawm NMN li cas tau raug soj ntsuam thiab tau txais. Lub ntiaj teb NMN raw khoom lag luam tau kwv yees tias yuav loj hlob ntawm kev loj hlob txhua xyoo ntawm kwv yees li 15-18% ntawm 2026 thiab 2030.[2]. Kev thov muaj zog tshwj xeeb hauv North America thiab Asia -Pacific, qhov twg cov neeg siv khoom tau paub ntau ntxiv txog kev tshawb fawb txog kev ua neej ntev.

Nyob rau tib lub sijhawm, qhov tseem ceeb ntawm kev yuav khoom tau hloov zuj zus. Qhov twg tus nqi ib zaug tau txiav txim siab- ua, cov neeg yuav khoom tam sim no tsom ntau dua rau kev huv, ruaj khov, thiab ntawv pov thawj. High-purity NMN (feem ntau ntau dua lossis sib npaug li 99%), txhawb nqa los ntawm thib peb- kev sim thiab ua raws li kev lees paub zoo, tau dhau los ua tus qauv kev lag luam.

Los ntawm peb sab ntawm Botanical Cube Inc., peb tau ua raws li peb cov tswv yim tsim khoom nrog cov kev xav tau hloov zuj zus. Peb siv cov txheej txheem enzymatic synthesis es tsis yog cov txheej txheem tshuaj ib txwm siv, uas tso cai rau peb txo qis impurities thiab tswj kom muaj kev sib raug zoo dua hauv cov khoom siv.

Peb qhov kev tsim khoom tau txais kev txhawb nqa los ntawm cov qauv kev lees paub thoob ntiaj teb, suav nrog cGMP, ISO22000, thiab FSSC22000, thiab txhua pawg tau txheeb xyuas los ntawm HPLC kev xeem kom paub meej purity saum 99%. Peb kuj muab cov lus qhia yooj yooj yim, suav nrog ntau qhov sib txawv thiab cov kev daws teeb meem tsim nyog rau cov tshuaj ntsiav, ntsiav tshuaj, lossis hmoov formulations.

Nrog rau ntau tshaj 20 xyoo ntawm kev paub nyob rau hauv cov khoom xyaw ntuj tsim, peb tsom mus rau kev xa tsis tau tsuas yog zoo, tab sis kuj ntev -lub sij hawm muab kev ruaj ntseg- tej yam uas tseem ceeb heev rau lub ntiaj teb no hom.

Saib ntawm daim duab tag nrho, qhov kev txiav txim siab ua kom pom tseeb. NAD⁺ tseem yog qhov tseem ceeb molecule nyob rau hauv nruab nrab ntawm cellular zog thiab los tiv thaiv- kev laus kev tshawb fawb, tab sis NMN sawv cev rau ib tug deb ntau lub tswv yim thiab ua tau zoo txoj kev los txhawb nqa NAD⁺ qib hauv lub cev. Nws zoo tshaj bioavailability, zoo -cov ntaub ntawv kho mob cov txiaj ntsig, thiab kev sib raug zoo nrog cov neeg siv khoom- cov qauv zoo ua rau nws qhov kev xaiv zoo tshaj plaws rau cov qauv tsim niaj hnub no.

Muab cov kev taw qhia tam sim no ntawm kev ua lag luam, xaiv tus neeg muag khoom NMN uas ntseeg siab tsis yog qhov kev txiav txim siab nrhiav khoom ntxiv lawm - nws yog ib qho kev xaiv. Yog tias koj tab tom npaj tsim cov khoom lag luam tshiab lossis kho cov qauv uas twb muaj lawm, peb nyob ntawm no los txhawb koj cov kauj ruam tom ntej. Hu rau peb ntawm:sales@botanicalcube.com.Peb npaj txhij los muab cov ntaub ntawv thev naus laus zis, cov qauv, thiab cov kev daws teeb meem customized raws li koj qhov kev lag luam.

[1] Mills, KF, Yoshida, S., Stein, LR, Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, ME, Apte, RS, Uchida, K., Yoshino, J., & Imai, S. (2016).Cell Metabolism, 568–79. https://doi.org/10.1016/j.cmet.2016.09.013

[2] Grand View Research. (2024).Anti-Txoj Kev Lag Luam Loj, Tshaj Tawm & Kev Tshawb Fawb Txog Kev Tshaj Tawm los ntawm cov khoom, los ntawm cov neeg pej xeem, los ntawm cheeb tsam, thiab ntu kwv yees, 2024-2030.
https://www.grandviewresearch.com/industry-analysis/anti-aging-market

[3] Grozio, A., Mills, KF, Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, HC, Zhong, L., Wu, R., Zhai, Y., et al. (2019).Slc12a8 yog nicotinamide mononucleotide transporter.Nature Metabolism, 1(1), 47–57.https://doi.org/10.1038/s42255-018-0009-4

[4] Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsui, M., Yamaguchi, S., et al. (2020).Effect of oral Administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in noj qab nyob zoo Japanese txiv neej.Endocrine Journal, 67(2), 153–160.https://doi.org/10.1507/endocrj.EJ19-0313

[5] Liao, B., Zhao, Y., Wang, D., Zhang, X., Hao, X., Hu, M., et al. (2021).Nicotinamide mononucleotide supplementation pab txhawb kev muaj peev xwm aerobic hauv cov neeg ncaws pob ncaws pob: Ib qho kev sib tw, ob npaug-kev tshawb nrhiav qhov muag tsis pom.Journal of the International Society of Sports Nutrition, 18(1), 54.https://doi.org/10.1186/s1242400-

[6] Yoshino, M., Yoshino, J., Kayser, BD, Patti, GJ, Franczyk, MP, Mills, KF, et al. (2021).Nicotinamide mononucleotide nce cov leeg nqaij insulin rhiab heev rau cov poj niam prediabetic.Science, 372(6547), 1224–1229.https://doi.org/10.1126/science.abe9985

[7] Martens, CR, Denman, BA, Mazzo, MR, Armstrong, ML, Reisdorph, N., McQueen, MB, et al. (2018).Chronic nicotinamide riboside supplementation yog zoo-tolerated thiab elevates NAD⁺ nyob rau hauv noj qab haus huv nruab nrab- laus thiab laus.Nature Communications, 9, 1286.https://doi.org/10.1038/s41467-018-0

[8] Imai, S., & Guarente, L. (2014).NAD⁺ and sirtuins in aging and disease.Trends in Cell Biology, 24(8), 464–471. https://doi.org/10.1016/j.tcb.2014.04.002

[9]ClinicalTrials.gov.A Kev Kawm los ntsuas Kev Nyab Xeeb thiab Kev Ua Haujlwm ntawm NMN.Identifier: NCT03151239 https://clinicaltrials.gov/ct2/show/NCT03151239