Raws li ib tugGingeroltsim tawm, Kuv txaus siab los ntawm gingerol thiab nws cov peev xwm kho mob. Hauv tsab xov xwm no, kuv yuav muab qhov tob tob saib seb gingerol yog dab tsi, nws cov txiaj ntsig rau cov teeb meem kev noj qab haus huv xws li tawv nqaij thiab mob thiab kev tshawb fawb tom qab nws ua haujlwm li cas.
Gingerol yog dab tsi?
Gingerolyog lub active phenolic compound pom nyob rau hauv tshiab qhiav uas muab lub hauv paus nws pungent, ntsim saj. Nws belongs rau cov chav kawm tshuaj hu ua phenols, uas muaj ib pawg hydroxyl sib koom ua ke rau lub nplhaib benzene.
Tshwj xeeb,gingerolmuaj ib tug ntev hydrocarbon saw txuas, cais nws raws li ib tug alkanol. Feem ntau hom pom nyob rau hauv Ginger yog6-gingerol, npe rau qhov chaw ntawm nws pawg hydroxyl ntawm 6th carbon nyob rau hauv cov saw. Txawm li cas los xij, ntau dua 30 cov txheej txheem ntsig txog gingerol tebchaw muaj nyob hauv Ginger hauv paus (1).
Hauv cov nroj tsuag,cov gingerolsua haujlwm tiv thaiv kev hem thawj xws li fungi, parasites, thiab predators. Thaum cov ntaub so ntswg puas lawm, gingerol synthase enzymes sai hloov phenylpropanoids mus rau hauv active gingerol constituents (2).
Nrog rau kev tiv thaiv cov nroj tsuag qhiav, gingerols muab kev pabcuam dav dav rau tib neeg. Cov txheej txheem kho mob ib txwm muaj xws li Ayurveda tau siv cov hauv paus hauv paus rau ntau pua xyoo los kho cov mob, xeev siab, mob, thiab lwm yam mob (3).
Kev tshawb fawb niaj hnub tam sim no tau lees paub ntau yam ntawm Ginger cov tshuaj siv tshuaj. Cov kev tshawb fawb qhia tau hais tias Ginger lub dav siv tshuaj kho mob feem ntau yog los ntawm nws cov ntsiab lus gingerol siab.
Lub Npe Lub Npe rau Gingerol yog dab tsi?
Gingerol tsis muaj lub npe "hom npe" sib nrug los ntawm nws lub npe tshuaj. Txawm li cas los xij, qee zaum nws raug xa mus rau tsis raug raws li:
Ginger phenol
Ginger phenolic
Gingerol phenol
Ginger paus tshuaj
Cov npe menyuam yaus no xa mus rau nws cov xwm txheej raws li phenol-type compound tau los ntawm qhiav. Tab sis gingerol tseem yog tus qauv lub npe siv kev tshawb fawb thiab kev lag luam.
hu nws yooj yim"Ginger paus active ingredient" kuj tsim nyog, raws li nws tseem ceebgingerol's xwm txheej raws li lub hauv paus tshuaj phytochemical nyob rau hauv Ginger rhizome.
Txawm hais tias tsawg dua, "qhiav extract"yog lwm lub npe nquag siv hauv kev lag luam ntxiv rau cov txheej txheem gingerol npaj. Tab sis nco ntsoov tias qhov tseeb qhiav extract muaj ntau lwm cov qhiav ntxiv tshaj li gingerol xwb.
Cov txiaj ntsig ntawm Gingerol
Kev tshawb fawb ntau lub cev qhia tau hais tias gingerol muab cov txiaj ntsig kho mob dav dav:
Anti-inflammatory - Gingerols muaj zog tiv thaiv ntau txoj hauv kev thiab cov neeg kho mob xws li NF-kB, COX-2, LOX, TNF-a, thiab IL-6 (4, 5)
Antioxidant - Gingerols pom cov dawb radical scavenging peev xwm piv rau vitamin E (6).
Anti-nausea - Gingerols khi serotonin thiab cholinergic receptors kom txo tau xeev siab thiab ntuav (7).
Analgesic - Gingerols txo qhov mob thiab o los ntawm inhibitory cuam tshuam rau inflammatory enzymes xws li phospholipase A2 (8).
Anti-microbial -Gingerolsmuaj tshuaj tua kab mob, tiv thaiv kab mob, thiab tshuaj tiv thaiv kab mob tiv thaiv kab mob tshuaj tiv thaiv kab mob (9, 10).
Anti-diabetic - Gingerols txhim kho insulin rhiab heev, txo cov ntshav qab zib, thiab tiv thaiv kev mob ntshav qab zib (11).
Anti-cancer - Gingerols induce cancer cell apoptosis, thiab inhibit proliferation thiab angiogenesis txoj kev (12).
Cardioprotective - Gingerols txo cov ntshav siab, roj cholesterol, platelet aggregation, thiab kev pheej hmoo ntawm atherosclerosis (13).
Neuroprotective - Gingerols tiv thaiv cov paj hlwb los ntawm kev puas tsuaj oxidative thiab txhim kho kev txawj ntse (14).
Qhov ntau ntawm cov txiaj ntsig gingerol ua rau nws muaj kev cog lus kho mob rau cov mob xws li mob caj dab mus rau ntshav qab zib mus rau mob qog noj ntshav thiab ntau dua. Txawm li cas los xij, kev noj tshuaj kom zoo, kev nyab xeeb, thiab kev ua tau zoo ntawm tib neeg tseem xav tau kev tshawb fawb ntxiv.
Gingerol Cov txiaj ntsig rau daim tawv nqaij
Ib qho ntawm cov txiaj ntsig zoo tshaj plaws gingerol garnering txaus siab yog nws cov teebmeem ntawm daim tawv nqaij noj qab haus huv thiab tsos. Raws li ib tug kws tshawb fawb dermatological, kuv tau muaj kev xav tshwj xeeb los ntawm gingerol lub peev xwm ua ib qho khoom siv kho tawv nqaij.
Txog tam sim no, ob qho tib si hauv vitro thiab tib neeg kev tshawb fawb qhia gingerol pab rau daim tawv nqaij los ntawm:
Ntxiv collagen synthesis - Gingerol txhawb kev ua haujlwm fibroblast thiab TGF- signaling los txhawb collagen ntau lawm (15).
Txo wrinkles thiab dryness - Gingerol ua rau cov tawv nqaij elasticity thiab hydration, ua rau daim tawv nqaij zoo li hluas (16).
Calming o - Gingerol inhibits qhov tso tawm ntawm inflammatory cytokines uas ua rau liab, o, thiab tawv nqaij mob xws li rosacea (17).
Tiv thaiv UV puas tsuaj - Gingerol tiv thaiv daim tawv nqaij los ntawm UVA / UVB photodamage thiab txo kev pheej hmoo ntawm mob qog noj ntshav (18).
Txhim kho pigmentation - Gingerol suppresses txoj hauv kev koom nrog hauv melanin overproduction thiab hyperpigmentation (19).
Sib ntaus pob txuv - Gingerol muaj cov tshuaj tua kab mob tiv thaiv kab mob P. acnes cuam tshuam rau pob txuv (20).
Accelerating qhov txhab kho - Gingerol ua kom lub sij hawm loj hlob ntawm kev kho mob los ntawm cellular thiab loj hlob stimulation (21).
Kev tshawb fawb tau zoo heev rau gingerol raws li kev tiv thaiv kev laus ntawm daim tawv nqaij. Kev siv tshuaj pleev ib ce, koob tshuaj qhov ncauj, lossis kev sib xyaw ua ke tuaj yeem yog cov tswv yim zoo. Ua tib zoo tsim cov kev sim no tseem xav tau kom paub meej tias muaj txiaj ntsig thiab tsim cov kev kho mob zoo tshaj plaws gingerol.
6-Gingerol Cov txiaj ntsig
Ntawm tag nrho cov txheej txheem muaj feem xyuam nrog gingerol tebchaw, 6-gingerol tau kawm ntau tshaj plaws. Kev tshawb fawb qhia tau tias 6-gingerol tsav ntau cov qhiav cov txiaj ntsig tshuaj los ntawm ntau cov txheej txheem:
Muaj zog antioxidant - 6-Gingerol tshem tawm cov dawb radicals thiab inhibits lipid peroxidation (22).
Muaj zog tiv thaiv kab mob - 6-Gingerol suppresses PGE2, LOX, COX-2, TNF-alpha, IL-6, thiab NF-kB (23).
Cov teebmeem analgesic - 6-Gingerol cuam tshuam nrog TRPV1 receptors thiab inhibits COX/LOX enzymes los txo qhov mob (24).
Anti-nausea - 6-Gingerol khi 5-HT3 receptors hauv plab kom txo tau xeev siab, ntuav, thiab vertigo (25).
Insulin sensitizing - 6-Gingerol nce GLUT4 translocation rau kev txhim kho cov piam thaj thiab insulin ua haujlwm (26).
Chemopreventive - 6-Gingerol induces cancer cell tuag los ntawm inhibition ntawm VEGF, BCL-2, thiab NFkB (27).
Txo cov roj (cholesterol) - 6-Gingerol txo tag nrho thiab LDL cov roj (cholesterol) los ntawm ntau lub tswv yim (28).
Neuroprotective - 6-Gingerol tiv thaiv cov hlwb neuronal los ntawm kev puas tsuaj oxidative thiab txhim kho kev txawj ntse (29).
Kom meej meej, 6-gingerol zoo li lub luag haujlwm rau ntau yam ntawm Ginger lub zog tshuaj thiab kev ua tau zoo ntawm cov tshuaj. Txawm li cas los xij, peb tseem tab tom nrhiav pom tag nrho cov peev txheej ntawm nws cov txheej txheem thiab tsim cov tswv yim pom zoo rau kev noj tshuaj.
Gingerol yog dab tsi?
Gingerol yog tsim los ntawm ob lub tsev loj: ib pawg phenolic thiab ib qho aliphatic alkane saw.
Lub hauv paus phenol qauv muab cov pab pawg hydroxyl (-OH) uas ua rau gingerol's antioxidant thiab anti-inflammatory zog. Qhov no suav nrog 6-carbon benzene nplhaib txuas rau -OH.
Cov saw alkane muab gingerol nws lipophilicity, uas ua rau kom nqus tau thiab bioactivity hauv lub cev. Qhov no muaj ib tug 5-9 carbon tail txuas rau phenol puag. Qhov ntev ntawm cov saw aliphatic no tsim txhua hom gingerol tshwj xeeb (piv txwv li 6-gingerol muaj 6-carbon tail).
Kev txiav tawm ntawm cov saw hlau alkane yog ntau pawg ua haujlwm xws li -OCH3 thiab -COOH uas hloov cov potency thiab pharmacokinetics. Ua ke, cov khoom no muab gingerols lawv cov chemistry thiab tshuaj zoo.
Hauv cov nroj tsuag qhiav, gingerols tshwm sim los ntawm phenylpropanoid precursors xws li cinnamic acid, coumaric acid, thiab caffeic acid. Gingerol synthase enzymes catalyze lub sib dhos ntawm phenol thiab alkane Cheebtsam rau biosynthesize active gingerols nyob rau hauv ginger cag hlwb (30).
Thaum muaj ntau tshaj 30 yam gingerols muaj nyob, 6-gingerol feem ntau yog qhov ntau tshaj, ua raws li 8-gingerol thiab 10-gingerol. Ntau hom Ginger thiab kev loj hlob hloov pauv qhov sib piv thiab potencies ntawm cov gingerols tsim.
Puas yog Gingerol Antibacterial?
Kev tshawb fawb dav dav pom tau tias gingerol muaj cov kab mob muaj zog tiv thaiv kab mob gram-positive thiab gram-negative kab mob. Cov ntawv ceeb toom qhia tias gingerol muaj txiaj ntsig zoo tiv thaiv ntau yam tshuaj tiv thaiv kab mob xws li:
E. coli - Gingerol puas cell membranes, depletes ATP, thiab tsub kom permeability (31).
S. aureus (MRSA) - Gingerol suppresses virulence yam thiab tsim biofilm (32).
P. aeruginosa - Gingerol inhibits quorum sensing, motility, thiab toxin secretion (33).
H. pylori - Gingerol tiv thaiv adhesion, nkag mus, thiab ua haujlwm urease (34).
S. mutans - Gingerol inhibits glucan tsim thiab cuam tshuam biofilm architecture (35).
Salmonella - Gingerol disintegrates daim nyias nyias thiab txo cov viability (36).
B. subtilis - Gingerol cuam tshuam rau daim nyias nyias, poov tshuaj to, thiab oxidative stress (37).
Gingerol's broad-spectrum antimicrobial kev ua tau zoo ua rau nws muaj kev vam meej tshuaj tua kab mob. Kev sib xyaw ua ke nrog cov tshuaj tua kab mob, nanoparticles, roj yam tseem ceeb, thiab lwm yam tuaj yeem txhim kho gingerol's antibacterial potency.
Gingerol ntau npaum li cas hauv Ginger?
Cov hauv paus tshiab Ginger muaj ntau yam ntawm 100-2200 mg gingerol ib kg, txawm hais tias ib txwm muaj qhov siab nruab nrab ~ 800-1200 mg / kg (38). Qhov feem ntawm cov gingerol tshwj xeeb sib txawv raws li hom kab qhiav, keeb kwm, thiab kev loj hlob.
Hauv cov ginger rhizome nyoos, 6-gingerol feem ntau yog ntau tshaj ntawm 200-470 mg/kg. 8-gingerol thiab 10-gingerol kuj tseem ua rau cov nyiaj tseem ceeb nyob ib ncig ntawm 130-220 mg/kg thiab 60-100 mg/kg, raws li (39).
Txawm li cas los xij, gingerols sai sai degrade thaum ziab thiab cua sov. Qhuav Ginger hmoov khaws cia tsuas yog 15-20 feem pua ntawm cov qhiav tshiab cov ntsiab lus gingerol. Thermal processing ntxiv txo cov qib gingerol txog li 50 feem pua (40).
Vim tsis muaj kev ruaj ntseg, cov ntaub ntawv zoo li cov qhiav hauv av thiab cov hlais qhuav muaj qhov txwv, cov tshuaj gingerol sib txawv. Rau cov qauv tsim muaj peev xwm, cov tshuaj muaj zog ruaj khov los yog oleoresins yog qhov zoo tshaj plaws, muab 5-15 feem pua gingerol.
Xwb, xaiv cov tshiab, nyoos Ginger hauv paus maximizes gingerol cov ntsiab lus. Siv 2-4 grams txhua hnub kom tau txais cov pov thawj raws li 100-200mg koob tshuaj gingerol. Ua hauj lwm nrog ib tus kws kho mob los txiav txim siab koj qhov kev pom zoo gingerol kom tsawg.
Dab tsi yog qhov nqus ntawm Gingerol?
Kev tshawb fawb qhia pom tias kev nqus gingerol hauv tib neeg ua raws li cov tshuaj phenol pharmacokinetics. Tom qab kev tswj hwm ntawm qhov ncauj gingerol, plasma concentration peaks nyob rau hauv 1-2 teev, qhia tau hais tias nce sai (41).
Txawm li cas los xij, qhov muaj peev xwm bioavailability tsuas yog txwv rau ~20-25 feem pua ntawm cov khoom noj khoom haus ua ntej dhau los (42). Lub aliphatic alkane saw zoo heev txhim kho gingerol lipophilicity thiab nqus tau piv rau lwm cov phenols.
Ib zaug nyob rau hauv kev ncig, gingerol accumulates nyob rau hauv cov ntaub so ntswg gastrointestinal. Txawm li cas los xij, nws kuj permeates ntau qhov chaw xws li cov kua dej sib koom, tawv nqaij, prostate, thiab cov ntaub so ntswg hlwb (43). phenolic -OH pab pawg tau dhau los ua glucuronidation thiab sulfation los tsim cov dej-soluble metabolites rau kev ua kom zoo.
Tag nrho kev tshem tawm ib nrab-lub neej nyob ntawm 2-3 teev. Tshaj 95 feem pua ntawm cov koob tshuaj tau tawm hauv 24 teev, feem ntau los ntawm cov kua tsib thiab tso zis. Txhawm rau tswj cov qib gingerol, noj txhua hnub hauv cov koob tshuaj sib faib yog qhov pom zoo (44).
Thaum gingerol nqus tau zoo, cov metabolism thiab tshem tawm sai. Txhim kho bioavailability los ntawm kev xa khoom, kev tso tawm, thiab kev sib xyaw nrog permeability enhancers yog qhov chaw tshawb fawb.
Dab tsi yog qhov cuam tshuam ntawm Gingerol?
Ntawm cov koob tshuaj ntawm 100-200 mg / hnub, gingerol tau txais txiaj ntsig zoo heev nrog kev nyab xeeb ntawm cov neeg feem coob. Txawm li cas los xij, qee qhov kev mob tshwm sim tuaj yeem suav nrog:
Kev kub hnyiab - tuaj yeem ua rau lub plab zom mov, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob reflux lossis ulcers (45).
Qhov ncauj lossis caj pas - Cov qhiav tshiab tuaj yeem ua rau kub hnyiab tau (46).
Kev ua xua - pob khaus, khaus, thiab o vim ginger rhiab heev lossis ua xua tshwm sim tsis tshua muaj (47).
Cov teeb meem los ntshav - koob tshuaj loj tuaj yeem ua rau muaj teeb meem hauv plab, thiab cuam tshuam nrog cov tshuaj tiv thaiv coagulants (48).
Tsis xis nyob - koob tshuaj ntau yuav ua rau tsam plab, mob plab, raws plab, thiab xeev siab (49).
Pw tsaug zog cuam tshuam - Ginger's stimulating teebmeem yuav ua rau qee qhov tsaug zog yog tias noj ua ntej pw (50).
Kev sib cuam tshuam yeeb tshuaj - Qhov no yuav ua rau kom nqus tau lossis cuam tshuam rau cov metabolism ntawm qee yam tshuaj (51).
Qhov kev pheej hmoo ntawm cov kev mob tshwm sim ntawm gingerol tuaj yeem txo qis los ntawm kev siv cov koob tshuaj kom tsim nyog, tsis txhob siv cov qhiav hnyav yog tias muaj kev cuam tshuam, thiab kev saib xyuas rau tus kheej kam rau ua. Nco ntsoov sab laj nrog koj tus kws kho mob ua ntej noj tshuaj ntxiv.
Qhov txiaj ntsig ntawm haus Ginger txhua hnub yog dab tsi?
Raws li kev tshawb fawb dav dav, tsis tu ncua haus cov tshuaj yej los yog qhiav dej muab cov pov thawj raws li cov txiaj ntsig kev noj qab haus huv:
Anti-Inflammatory - Mob mob yog nyob rau hauv lub hauv paus ntawm feem ntau cov kab mob. Gingerol inhibits cov cim inflammatory xws li CRP, INF-gamma, thiab cytokines (52).
Immunity Boost - Gingerol txhim kho T lymphocyte thiab NK cell kev ua kom muaj zog tiv thaiv kab mob (53).
Nausea Relief - Ginger tshuaj yej ntseeg tau yooj yim kho ntau hom xeev siab los ntawm kev mob hnyav mus rau kev kho mob (54).
Kev them nyiaj yug Detox - Gingerol stimulates lymphatic ncig thiab daim siab detoxification txoj hauv kev (55).
Lub Plawv Pab - Gingerol txhim kho lipid profile, txo cov ntshav siab, thiab tiv thaiv platelet aggregation (56).
Kev txo qis - Ntawm COX / LOX inhibition, gingerol txo qis migraines, mob caj dab, PMS, thiab lwm yam mob (57).
Lub hlwb muaj nuj nqi - Gingerol tiv thaiv kev paub txog kev poob qis thiab neurodegeneration los ntawm cov txheej txheem antioxidant (58).
Cov txiaj ntsig sib txawv ua rau niaj hnub siv cov qhiav zoo tagnrho rau kev txhawb nqa tag nrho kev noj qab haus huv thiab tiv thaiv kab mob. Haus 1-3 khob ntawm cov tshuaj yej tshiab qhiav, txaus siab rau cov qhiav hauv dej los yog noj cov tshuaj ntsiav tshuaj ntxiv.
Txhawm rau tso qhov kev txiav txim rau Gingerol, thov hu rau peb ntawm sales@botanicalcube.com.
Cov ntaub ntawv:
Semwal RB et al. Gingerols thiab shogaols: Cov ntsiab lus tseem ceeb nutraceutical los ntawm Ginger. Phyther Res. Peb Hlis 29, 2015: 1630-46.
Prasad S, Tyagi AK. Ginger thiab nws cov khoom xyaw: lub luag haujlwm hauv kev tiv thaiv thiab kho mob qog noj ntshav hauv plab. Gastroenterol Res Xyaum. Xyoo 2015; 2015: 142979.
Ali BH et al. Qee cov phytochemical, pharmacological thiab toxicological zog ntawm Ginger (Zingiber officinale Roscoe): Kev tshuaj xyuas ntawm kev tshawb fawb tsis ntev los no. Khoom noj khoom haus Chem Toxicol. 2008 Feb;46(2):409-20.
Mashhadi NS et al. Anti-oxidative thiab anti-inflammatory teebmeem ntawm qhiav hauv kev noj qab haus huv thiab lub cev ua haujlwm: tshuaj xyuas cov pov thawj tam sim no. Int J Prev Med. 2013;4(Suppl 1):S36-S42.
Raman M, Dewhurst O. Kev Kho Mob Muaj Peev Xwm ntawm Ginger hauv Kab Mob plab hnyuv. Khoom noj khoom haus. 2020 Nov 8; 12(11):3376.
Stoilova I et al. Antioxidant kev ua haujlwm ntawm Ginger Extract (Zingiber officinale). Khoom noj khoom haus Chem. 2007 Jan; 102(3):764-770.
Marx W et al. Ginger-Mechanism of action in chemotherapy-induced xeev siab thiab ntuav: Kev tshuaj xyuas. Crit Rev Food Sci Nutr. 2017 Jan 2;57(1):141-146.
Terry R et al. Kev Siv Ginger (Zingiber officinale) rau Kev Kho Mob: Kev Tshawb Fawb Txog Kev Kho Mob. Mob Med. 2011 Dec; 12(12):1808-18.