Dihydromyricetin (DHM) yog ib qho khoom siv ntuj tsim uas tsis ntev los no tau muaj koob meej raws li kev ntxiv los txo cov teebmeem ntawm cawv cawv. Tab sis yog noj DHM tiag tiag? Hauv cov ntawv tshaj tawm no, peb yuav tshawb xyuas seb DHM yog dab tsi, nws ua haujlwm li cas, nws qhov profile muaj kev nyab xeeb, muaj peev xwm tshwm sim, thiab noj kom raug.
Dihydromyricetin yog dab tsi?
Dihydromyricetin (DHM) yog ib qho flavonoid compound pom nyob rau hauv ntau yam nroj tsuag thiab tshuaj ntsuab xws li Japanese raisin ntoo, Hovenia dulcis. Nws tau ntev tau siv nyob rau hauv cov tshuaj suav tshuaj raws li kev kho mob hangover thiab intoxication tiv thaiv.
Chemically, DHM yog muab los ntawm flavonoid ampelopsin thiab muaj cov qauv molecular zoo sib xws rau myricetin. Nws muaj zog antioxidant zog vim nws cov tshuaj muaj pes tsawg leeg. DHM kuj tseem tuaj yeem cuam tshuam GABA receptors thiab cawv dehydrogenase enzymes los tiv thaiv cov teebmeem ntawm cawv.
Kev nyab xeeb Profile ntawm Dihydromyricetin
Toxicity Studies
Ntau cov kev tshawb fawb toxicity tau ua tiav ntawm DHM los tsim kom muaj kev nyab xeeb thiab muaj peev xwm tshwm sim. Cov kev tshawb fawb tsiaj uas muaj cov nas thiab nas tau siv koob tshuaj DHM txij li 100-5000 mg/kg lub cev hnyav nrog me me kom tsis muaj tshuaj lom.
Ib txoj kev tshawb fawb tau muab cov nas rau ib koob ntawm 5000 mg / kg DHM thiab pom tsis muaj kev tuag lossis cov tsos mob ntawm toxicity. Kev soj ntsuam toxicity ntev kuj tsis pom muaj qhov tsis zoo ntawm DHM thaum muab rau nas rau 30 hnub ntawm koob tshuaj txog 1000 mg / kg. Zuag qhia tag nrho, kev tshawb fawb tsiaj qhia tau hais tias DHM muaj qhov kev nyab xeeb siab thiab qhov nruab nrab tus neeg tuag koob tshuaj (LD50) tseem tsis tau tsim.
Tib neeg cov kev sim tshuaj kho mob tau lees paub ntxiv txog kev nyab xeeb ntawm DHM ntawm ntau npaum li cas siv los ua kev kho mob hangover lossis cawv cawv tiv thaiv. Kev noj ntau npaum li 1000-1200 mg txhua hnub rau ob peb lub lis piam tsis pom muaj qhov tshwm sim tsis zoo. Cov kev tshawb fawb tib neeg feem ntau siv ib koob tshuaj ntawm 300-600 mg uas tshwm sim ob qho tib si zoo thiab nyab xeeb.
Tej yam tshwm sim
Txawm hais tias nws qhov profile muaj kev nyab xeeb siab, qee qhov kev phiv me me tau cuam tshuam nrog kev siv DHM. Feem ntau tshaj tawm muaj xws li xeev siab, plab tsis xis nyob, kiv taub hau, thiab mob taub hau. Txawm li cas los xij, cov teebmeem no zoo li mob me.
Ib txoj kev tshawb fawb tau muab cov neeg koom nrog ib koob tshuaj 600 mg ntawm DHM hmoov thiab 9 feem pua tau ntsib qee qhov mob plab uas daws tau sai. Lwm qhov kev sim siv txhua hnub 300-500 mg koob tshuaj rau ib lub lis piam qhia qee zaus kiv taub hau thiab xeev siab hauv ib feem me me ntawm cov neeg siv. Tab sis tag nrho, DHM tau txais txiaj ntsig zoo heev tshwj xeeb ntawm cov koob tshuaj qis dua 600 mg.
Allergies thiab Sensitivities
Tsis muaj cov ntaub ntawv qhia txog kev tsis haum tshuaj lossis kev nkag siab tshwj xeeb rau DHM. Txawm li cas los xij, nws muaj peev xwm ua rau cov neeg muaj kev fab tshuaj rau cov nroj tsuag xws li Japanese raisin tsob ntoo tuaj yeem ntsib kev fab tshuaj. Cov no yuav muaj xws li pob khaus, khaus, lossis o. Cov uas muaj rhiab heev rau lwm cov flavonoids xws li myricetin kuj tuaj yeem ua rau.
Nws raug nquahu kom sab laj nrog kws kho mob ua ntej noj DHM yog tias koj muaj kev fab tshuaj rau cov nroj tsuag lossis zaub mov, tshwj xeeb tshaj yog rau txiv hmab txiv ntoo, raisins, lossis cawv. Tso tseg kev siv yog tias muaj kev khaus khaus lossis tsis xis nyob. DHM tsis tshwm sim feem ntau ua rau muaj kev tsis haum tshuaj tab sis yuav tsum ceev faj siv cov neeg uas muaj kev fab tshuaj rau cov nroj tsuag / zaub mov.
Puas yog Dihydromyricetin ua haujlwm tiag tiag?
Ntau qhov kev sim ntawm tib neeg tau pom tias DHM tuaj yeem txo qis ntshav cawv, txo cov tsos mob hangover, thiab tiv thaiv kev qaug cawv. Cov txheej txheem tom qab cov teebmeem no tseem tab tom kawm tab sis yuav muaj feem cuam tshuam rau cawv dehydrogenase enzymes thiab GABA receptors.
Hauv kev tshawb nrhiav cov tshuaj placebo, cov neeg koom nrog noj 300 mg koob tshuaj DHM ua ntej haus dej haus cawv muaj cov ntsiab lus siab tshaj plaws ntawm cov ntshav mus txog 36 feem pua qis dua li cov placebo. Kev ntsuas kev quav yeeb quav tshuaj kuj tau txo qis los ntawm 23-50 feem pua hauv ntau yam kev ntsuam xyuas psychomotor. DHM kuj tau pom tias txhim kho lub sijhawm tshem tawm cawv thiab txo qhov mob hnyav tag nrho.
Tsis yog txhua qhov kev tshawb fawb tau pom tias muaj kev cuam tshuam loj heev thiab cov txiaj ntsig zoo li sib txawv raws li DHM ntau npaum, haus cawv, thiab tus kheej lub cev. Tab sis feem ntau ntawm kev tshawb fawb qhia tias DHM tuaj yeem pab txo qis kev qaug cawv, ua rau qaug cawv, txhim kho kev sib koom tes ntawm lub cev, thiab tuaj yeem pab txhawb kev haus cawv. Kev tshawb fawb ntxiv tseem xav tau ntawm nws cov txheej txheem ntawm kev ua.
Puas yog Dihydromyricetin txwv tsis pub koj haus cawv?
Txawm hais tias qee cov xov xwm zoo siab tau hais tawm, DHM tsis tshwm sim kom nres lossis tiv thaiv kev qaug cawv. Nws feem ntau pab txo qis cov ntshav dej cawv thaum haus thiab txo cov tsos mob hangover rau hnub tom qab.
Feem ntau cov kev tshawb fawb qhia DHM txo cov kev xav ntawm kev qaug dej qaug cawv los ntawm 20-50 feem pua , tab sis tsis tag rau ib tug neeg uas tau haus dej ntau heev. Txawm li cas los xij, nws yuav pab tau ib tus neeg hnov ntau lub taub hau yog tias lawv tsuas haus 1 lossis 2 haus xwb.
Rau cov uas xav kom nyob twj ywm tsis tsaug zog, DHM yuav tsum tsis txhob siv rau qhov chaw ntawm kev xyaum ua kom zoo lossis tsis txhob haus cawv. Xav txog nws ntau dua li cov cuab yeej txo kev puas tsuaj los pab tshem tawm cov xwm txheej hauv zej zog, tsis yog qee yam uas yuav ua rau koj qaug dej qaug cawv yam tsis muaj qhov tshwm sim. DHM ntxiv lub luag haujlwm ntawm tus kheej, tab sis tsis hloov nws.
Kuv yuav tsum noj Dihydromyricetin ntau npaum li cas?
Feem ntau cov kev tshawb fawb tau siv DHM koob tshuaj ntawm 300-600 mg uas zoo nkaus li zoo thiab nyab xeeb. Tsawg npaum li 100-200 mg yuav muab qee cov txiaj ntsig, tab sis cov koob tshuaj loj dua nyob ib ncig ntawm 300-500 mg zoo li ua haujlwm zoo tshaj rau ntau tus neeg. Txhua yam dhau 600 mg hauv ib koob tshuaj tsis tshwm sim los txhim kho kev ua tau zoo ntau dua.
Nws yog qhov zoo tshaj plaws los pib ntawm qis kawg ntawm 200-300 mg thiab saib seb koj teb li cas. DHM tuaj yeem noj tau 30-60 feeb ua ntej haus, lossis ua ntej pw tom qab ib hmos haus dej ntau los txo cov tsos mob hangover. Nws kuj tseem yuav muab faib ua ob koob tshuaj - ib qho ua ntej haus thiab ib qho ua ntej pw.
Rau kev noj tshuaj txhua hnub, tag nrho cov nyiaj ntau dua 600 mg ib hnub tsis muaj kev tshawb fawb txog kev nyab xeeb txaus. Feem ntau cov kev tshawb fawb soj ntsuam kev noj tshuaj DHM ntev ntev siv 300 mg faib cov koob tshuaj thaum sawv ntxov thiab hmo ntuj. Nws yog qhov zoo tshaj rau so ntawm 1-2 lub lis piam tom qab siv DHM ob peb hnub ua ke.
Dab tsi yog qhov cuam tshuam ntawm Dihydromyricetin?
Cov teebmeem tseem ceeb ntawm DHM suav nrog:
- Txo qis cov ntshav cawv ntau ntau thiab lawv qhov nce ntxiv nrog kev haus cawv
- Txo cov kev xav ntawm kev qaug cawv thiab qaug cawv
- Kev tiv thaiv cawv los ntawm kev sib koom ua ke ntawm lub cev muaj zog thiab kev paub
- Ceev kom tshem tawm cawv los ntawm cov hlab ntsha
- Tshem tawm cov tsos mob hangover tom ntej xws li mob taub hau, xeev siab, qaug zog, thiab vertigo
Cov teebmeem no tso cai rau DHM hmoov los pab "txiav ntug" cawv yam tsis muaj kev cuam tshuam tag nrho. Nws muab qhov tsis zoo los pab koj kom tsis txhob ua kom dub lossis txiav txim siab tsis zoo thaum haus. Cov teebmeem no pom tau tab sis hloov maj mam - tsis txhob cia siab tias nws yuav ua rau koj tsis tsaug zog yog tias noj cov cawv hnyav.
Leej Twg Yuav Tsis Noj DHM?
DHM zoo li muaj kev nyab xeeb rau tib neeg feem coob, tab sis qee cov neeg yuav tsum tau ceev faj lossis tsis txhob siv:
- Cov neeg uas haus cawv los yog haus dej haus cawv - DHM tuaj yeem ua rau haus ntau dhau
- Cov neeg muaj kab mob siab - DHM tuaj yeem ntxhov siab rau lub siab ua haujlwm tsis zoo
- Cov poj niam cev xeeb tub los yog pub niam mis - Tsis muaj kev tshawb fawb txog kev nyab xeeb rau tus me nyuam hauv plab los yog menyuam yaus
- Cov menyuam yaus hnub nyoog qis dua 18 - Tsis muaj kev tshawb fawb txog kev nyab xeeb hauv pawg hnub nyoog no
- Cov neeg haus cawv ua rau cov tshuaj zoo li metronidazole - tuaj yeem ua rau muaj kev cuam tshuam tsis zoo nrog cawv
- Cov neeg uas muaj tsob ntoo raisin lossis zaub mov tsis haum - Muaj peev xwm hla-reactivity thiab ua xua
Yog tias tsis ntseeg, sab laj nrog kws kho mob ua ntej noj DHM tshwj xeeb yog tias koj muaj mob lossis noj tshuaj uas cuam tshuam. Thaum feem ntau ua tau zoo, cov neeg uas muaj lub siab ua haujlwm tsis zoo yuav xav siv kev ceev faj tshwj xeeb nrog DHM vim nws cov metabolism thiab tshem tawm los ntawm lub siab. Kev tshawb fawb ntxiv tseem xav tau ntawm qhov muaj peev xwm mus sij hawm ntev nrog kev siv ntau npaum li cas.
Hauv cov ntsiab lus, thaum siv lub luag haujlwm DHM zoo li muaj qhov dav dav kev nyab xeeb. Tam sim no tsis muaj ntawv tshaj tawm txog kev ua kom tuag taus ntau dhau lossis cov xwm txheej tsis zoo, txawm tias muaj ntau npaum li cas. Cov kev mob me me xws li xeev siab thiab kiv taub hau tuaj yeem tshwm sim tab sis yog ib ntus. Tham nrog koj tus kws kho mob yog tias noj tshuaj lossis muaj mob ua ntej siv DHM tshuaj. Kev tshawb fawb ntxiv tseem tau lees paub txog qhov muaj feem cuam tshuam mus ntev. Tab sis cov ntaub ntawv pov thawj tam sim no qhia tias DHM tuaj yeem yog ib qho kev pab cawv zoo thaum siv los ntawm cov neeg laus noj qab haus huv.
Yog tias koj txaus siab tau txais cov khoom lag luam zoo Tuam Tshoj Dihydromyricetin Powder, Botanical Cube Inc. yog ib tus neeg muag khoom tshaj lij. Yog xav paub ntxiv los yog tso ib qho kev txiav txim, thov hu rau peb ntawmsales@botanicalcube.com.
Cov ntaub ntawv:
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2. Liu, Q., Duan, J., Tang, Y., Guo, J., Kong, L., Wang, S., ... & Su, S. (2015). Dihydromyricetin txhim kho cov piam thaj thiab lipid metabolism thiab ua rau muaj kev tiv thaiv kab mob hauv cov kab mob uas tsis yog-coholic fatty siab: Kev sim tshuaj randomized. Pharmacological Research, 99, 74-81.
3. Jing, L., Li, Y., Zhao, R., Xing, J., Fu, Q., Li, S., & Sun, H. (2015). Dihydromyricetin tiv thaiv kev mob siab rau lub siab los ntawm kev ua kom dej cawv metabolism thiab txo qis oxidative kev nyuaj siab. Biological and Pharmaceutical Bulletin, 38(3), 371-378.
4. Xing, J., Wang, B., Niu, Y., Dong, R., Yan, H., Li, S., ... & Sun, H. (2014). Dihydromyricetin tiv thaiv kev haus cawv ua rau lub siab oxidative raug mob los ntawm kev txhim kho aldehyde dehydrogenase 2 qhia. European Journal of Pharmacology, 723, 68-74.
5. Wang, M., Sun, R., Zhou, Y., Zhang, H., Yang, X., Zheng, Y., ... & Li, C. (2016). Dihydromyricetin txhim kho cerebrovascular muaj nuj nqi nrog antioxidation thiab yog neuroprotective nyob rau hauv A-injected nas hlwb. Oxidative Medicine thiab Cellular Longevity, 2016.
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