Puas yog NMN Tsuas yog Vitamin B3?

Thaum kuv xub kawm txog Nicotinamide Mononucleotide (NMN), cov lus nug tam sim no yog: "Puas yog lwm cov vitamin B?" Kuv paub koj ntau tus, peb txoj kev noj qab haus huv -cov neeg siv khoom thoob ntiaj teb paub, muaj qhov tsis meej pem. Tom qab tag nrho, NMN thiab Vitamin B3-tseem hu ua Niacin-qhia ib tsev neeg tsob ntoo.Qhov Tseeb Yooj Yim:NMNyog ib qho derivative ntawm Vitamin B3, tab sis cia kuv paub meej: NMN tsis yog vitamin B3 xwb. Sib npaug lawv zoo li hu rau lub dav hlau lub cav tsheb kauj vab -lawv yog cov txheej txheem muaj feem cuam tshuam rau hauv txoj kev metabolic, tab sis lawv lub zog, kev ua haujlwm, thiab qhov chaw sib txawv heev.

Zaj dab neeg tiag tiag nyob rau hauv dab tsi NMN thaum kawg sim ua kom tiav: dhau los ua Nicotinamide Adenine Dinucleotide (NAD +) molecule. NAD + yog lub hnub qub tiag tiag, thiab NMN yog txoj hauv kev ncaj ncees tshaj plaws, peb tam sim no yuav tsum tau txhawb nqa nws cov qib.Peb yuav taug kev los ntawm cov chemistry yooj yim mus rau kev txiav- ntug kev tshawb fawb thiab kev lag luam sib txawv los muab cov lus teb meej meej rau koj, tso cai rau koj los txiav txim siab xaiv txog koj txoj kev mus ntev.

Txhawm rau nkag siab tias vim li cas NMN yog kev hloov kho lom neeg los ntawm ib txwm muaj B3, peb yuav tsum saib lawv cov qauv tshuaj thiab cov luag haujlwm uas lawv ua hauv lub xov tooj ntawm tes "lub Hoobkas."

A. Tsev Neeg Vitamin B3: Lub Tsev Blocks

Vitamin B3 yog lub ntsiab lus kaus, feem ntau xa mus rau ob hom:

Nicotinic Acid (NA), los yog Niacin.

Nicotinamide (NAM), los yog Niacinamide.

Ob leeg NA thiab NAM raug suav hais tias yog qhov tsis ncaj qha ua ntej rau NAD+. Peb lub cev yuav tsum ua ntej hloov lawv los ntawm ntau cov kauj ruam kom thiaj li tau txais txiaj ntsig NAD +, feem ntau yog los ntawm qhov dej zoo -paub Salvage Pathway.

B. NMN: Npaj- los-Siv Cheeb Tsam

NMN (Nicotinamide Mononucleotide) yog ze rau ntawm txoj kab tiav.

1. Cov qauv sib txawv: Saib ze ntawm cov molecules:NAM yog qhov yooj yim. NMN, ntawm qhov tod tes, ntxiv ob lub qauv tseem ceeb rau NAM puag: ribose qab zib thiab pab pawg phosphate. Qhov no yog qhov kev ua si - hloov pauv.

2. Txoj Kev Ncaj Ncees:Vim hais tias ntawm no ntxiv complexity, NMN yog lub tswv yim positioned kom ncaj qha hloov mus rau hauv NAD + nrog tsawg zog los ntawm lub cell.Thaum lub cev xav tau NAM los tsim NMN, ntxiv nrog rau cov NMN molecule nws tus kheej bypasses ib qho tseem ceeb, feem ntau npaum li cas - txwv, cov kauj ruam hauv cov txheej txheem. Qhov no ua rau NMN muaj txiaj ntsig zoo dua thiab ncaj qha NAD + ntxiv: Vitamin B3 (NAM) → NMN → NAD +

3. Lub ntsiab lus tseem ceeb:NAD + (Nicotinamide Adenine Dinucleotide) tsis yog lwm cov molecule; Nws yog ib qho tseem ceeb coenzyme pom nyob rau hauv txhua lub cell ntawm koj lub cev. Nws ua cov roj rau cov txheej txheem tseem ceeb ntawm tes, suav nrog kev tsim hluav taws xob, kho DNA, thiab kev nthuav qhia noob. Xav tias nws yog txiaj ntsig ntawm cellular noj qab haus huv.

Qhov kev zoo siab nyob ib puag ncig NMN tshwm sim los ntawm kev tshawb pom kev tshawb fawb txuas nrog NAD + poob rau cov txheej txheem kev laus.

A. NAD+ thiab Clock of Aging

Kev tshawb fawb pom tseeb, tshwj xeeb los ntawm cov kws tshawb fawb xws li Dr. David Sinclair ntawm Harvard, tau hais tias thaum peb muaj hnub nyoog, peb cov NAD + qib qis qis tshaj li 50% ntawm hnub nyoog 40 thiab 60. Qhov kev poob no yog qhov tseem ceeb ntawm lub hnub nyoog - cuam tshuam poob [1].

Vim li cas qhov no tseem ceeb heev? NAD + yog qhov tseem ceeb rau kev ua kom cov proteins tseem ceeb:

1. Sirtuins (SIRTs):Feem ntau hu ua "ntev cov proteins," cov enzymes no tseem ceeb heev rau kev tswj cov genomic stability thiab metabolic noj qab haus huv. Sirtuins tsis tuaj yeem ua haujlwm yam tsis muaj NAD+.

2. PARPs (Poly-ADP-ribose polymerases):Cov enzymes no tseem ceeb heev rau kev kho DNA puas. Raws li DNA puas ntsoog ntau dhau sijhawm, PARPs siv ntau ntawm NAD + los kho, ntxiv rau cov khoom siv cellular depleting.

B. Cov Ntawv Pov Thawj: Tsiaj thiab Kev Tshawb Fawb Txog Tib Neeg Thaum Ntxov

Thaum kev tshawb fawb tseem tsis tu ncua, qhov kev tshawb pom thawj zaug ntawm NMN qhov kev ua tau zoo tau txhawb nqa thiab muab cov kev tshawb fawb tob tob uas cov neeg siv khoom xav tau.

1. Tsiaj Model Success

Hauv ntau qhov kev tshawb fawb nas, NMN supplementation tau pom cov txiaj ntsig zoo. Piv txwv li, hauv kev tshawb fawb luam tawm hauv Cell Metabolism, nas tau txais NMN tau pom tias muaj kev ua haujlwm ntawm mitochondrial thiab kev ua siab ntev zoo dua, nrog cov nas laus khiav mus txog 56% deb dua li un- cov khoom sib txuas ntxiv [2]. Lwm cov kev tshawb fawb tau pom tias NMN tau txais txiaj ntsig rov qab cov cim ntawm kev laus hauv daim siab thiab pob txha pob txha.

2. Human Clinical Trials on Metabolism

Thaum ntxov- kev sim tib neeg theem tau tsom mus rau kev nyab xeeb thiab ua tau zoo hauv kev txhawb nqa NAD+ qib. Kev sim tsom rau cov poj niam laus Nyij Pooj tau pom tias 250 mg ntawm NMN ib hnub rau 12 lub lis piam ua rau muaj kev txhim kho tseem ceeb hauv cov leeg nqaij thiab insulin rhiab heev piv rau cov placebo pab pawg, qhia txog cov txiaj ntsig ncaj qha metabolic [3]. Lwm txoj kev tshawb fawb tau hais tias NMN supplementation (txog 500 mg txhua hnub) tau raug zam kom nyab xeeb thiab ua tau zoo nce NAD + metabolites hauv cov ntshav, muab kev lees paub tseem ceeb ntawm nws cov txheej txheem hauv tib neeg [4].

Cov txiaj ntsig no tau pom zoo tias NMN muaj peev xwm tiv thaiv lub hnub nyoog - cuam tshuam NAD + poob qis, muab txoj hauv kev tshiab rau kev txhawb nqa kev noj qab haus huv thiab cellular.

Qhov kev zoo siab ntawm kev tshawb fawb tau txhais tau meej meej rau hauv kev lag luam booming, underscoring NMN qhov kev paub txog tus nqi thiab kev ntseeg siab ntawm cov neeg siv khoom thoob ntiaj teb.

A. Kev Ua Lag Luam Ntev Ntev

Lub ntiaj teb Nicotinamide Mononucleotide (NMN) kev ua lag luam, uas muaj nuj nqis kwv yees li ntawm USD $ 210 txog $ 360 lab hauv 2024, tau kwv yees tias yuav loj hlob ntau, nrog rau ntau cov ntaub ntawv kwv yees qhov muaj zog Compound Annual Growth Rate (CAGR) ntawm 8.2% mus rau ntau dua 10% txog 2030.

Qhov kev loj hlob tawg tawg no yog tsav los ntawm:

1. Cov Neeg Laus Thoob Ntiaj Teb:Tib neeg nyob ntev dua thiab nquag nrhiav kev daws teeb meem los tswj kev noj qab haus huv- pes tsawg xyoo nyob hauv kev noj qab haus huv.

2. Kev nce ntawm Biohacking:Cov neeg siv khoom txawv teb chaws, tshwj xeeb hauv North America thiab Europe, tab tom lees txais "Biohacking" lub tswv yim, uas suav nrog kev siv cov ntaub ntawv thiab kev tshawb fawb -cov khoom txhawb nqa los txhim kho kev ua tau zoo thiab ua haujlwm ntev. NMN tau dhau los ua lub hauv paus ntawm qhov kev txav no.

B. Zoo thiab kev thov

Qhov kev thov siab tau ua rau kev ua lag luam sib tw, yuam cov neeg siv khoom ua ntej ua ntej purity, zoo, thiab pob tshab. Lub hom phiaj tau hloov pauv los ntawm kev yuav khoom "B3" mus rau kev yuav khoom siv tau raug tshawb fawb, siab -purity NMN. Cov neeg siv khoom tam sim no nquag nrhiav cov khoom lag luam nrog 99%+ purity thiab tau lees paub qhov thib peb -kev xeem.

Muab cov ntsiab lus kev tshawb fawb thiab kev lag luam no, peb nkag siab tias koj xav tau cov khoom lag luam uas phim cov lus cog tseg ntawm NMN. Qhov no yog vim li cas peb tshwj xeeb hauv siab -purity NMN hmoov.

A. Lub hwj chim ntawm hmoov

Thaum cov tshuaj ntsiav yooj yim, peb tawm tswv yim rau daim ntawv hmoov rau ntau yam laj thawj:

1. Purity & Transparency

Hmoov tso cai rau peb kom yooj yim txheeb xyuas thiab tswj tau qhov ultra- siab purity ntawm 99%+. Peb ntseeg hauv radical transparency, thiab peb cov batch- tshwj xeeb Thib Peb-Party Lab Reports yog peb cov ntaub ntawv tsis yog - cov ntaub ntawv pov thawj ntawm qhov zoo.

2. Siv tau yooj yim thiab meej

NMN taug kev yog tus kheej. Hmoov tso cai rau koj los ntsuas qhov tseeb thiab kho koj cov koob tshuaj raws li koj lub cev xav tau thiab koj tus kws kho mob cov lus qhia.

3. Ua kom muaj peev xwm nqus tau

Ntau tus ntawm peb cov neeg siv khoom xaiv cov lus sublingual (hauv qab -- tus nplaig)) txoj kev nrog cov hmoov. Txoj kev no tso cai rau NMN tau nqus ncaj qha mus rau hauv cov hlab ntsha, muaj peev xwm hla lub plab zom mov thiab muab cov khoom noj muaj txiaj ntsig zoo dua piv rau cov qauv kev noj qab haus huv.

B. Botanical Cube Kev cog lus: Zoo Koj tuaj yeem ntseeg tau

Peb tsis yog muag NMN xwb; peb muab cov molecule uas sawv cev rau qhov kawg ntawm kev tshawb fawb los tiv thaiv -aging.

Peb cov NMN hmoov yog tsim nyob rau hauv nruj cGMP (Tam sim no Zoo Manufacturing Practice) cov qauv, xyuas kom meej txhua txhua scoop ua tau raws li qhov zoo tshaj plaws thoob ntiaj teb qhov pib. Thaum koj xaiv Botanical Cube, koj tsis yog yuav khoom ntxiv; koj tab tom nqis peev hauv cov khoom lag luam uas tau lees paub los ntawm kev tshawb fawb thiab tsim nrog kev ncaj ncees.Siv peb cov hmoov NMN ncaj qha, ua tau zoo, thiab txhawb nqa koj cov cellular noj qab haus huv thiab lub zog. Tsis txhob khom rau indirect precursors; xaiv txoj hauv kev zoo los txhawb koj qib NAD + thiab ua rau koj qhov tseem ceeb!

Puas yog NMN tsuas yog Vitamin B3 xwb?Cov lus teb tseeb yog Tsis yog. Thaum NMN tau los ntawm tsev neeg B3, nws cov qauv molecular, nws lub luag haujlwm ncaj qha metabolic raws li lub zog NAD + precursor, thiab nws cov ntaub ntawv tshawb fawb txog kev ua neej nyob ntev tshaj li qhov yooj yim vitamin. Nws sawv cev rau kev nce qib tseem ceeb hauv cov khoom noj khoom haus molecular thiab kev tiv thaiv kev laus -.

Lub neej yav tom ntej ntawm kev noj qab haus huv thiab kev ua neej ntev yog hloov los ntawm kev kho mob rov qab mus rau kev txhawb nqa cellular. Raws li kev sim tib neeg nruj dua tau tshaj tawm, NMN lub luag haujlwm ua lub hauv paus tseem ceeb hauv kev noj qab haus huv niaj hnub no tsuas yog ntxiv dag zog.Rau cov ntaub ntawv ntxaws ntxiv, peb cov lus tshaj tawm thib peb thib ob -, lossis los tham txog cov kev daws teeb meem loj rau koj lub lag luam, thov tsis txhob yig tiv tauj peb. Hu rau peb Hnub no: Email:sales@botanicalcube.com. Cia peb pab koj nkag mus rau qhov zoo tshaj plaws NMN hmoov ntawm lub lag luam thoob ntiaj teb.

Kev siv

[1] Source: Sinclair, DA, & LaPlante, A. (2019). Lifespan: Vim Li Cas Peb Hnub Nyoog -thiab Vim Li Cas Peb Tsis Muaj. Atria Phau ntawv.

Cov ntsiab lus: Siv los txhawb cov nqe lus dav dav hais txog lub hnub nyoog - cuam tshuam txog kev poob qis ntawm NAD + thiab nws lub luag haujlwm tseem ceeb hauv kev ua kom Sirtuins (ntev ntev proteins) thiab PARPs (DNA kho enzymes). Qhov no yog qhov kev lees paub dav dav siv hauv thaj chaw.

[2] Source: Mills, KF, Yoshida, S., Stein, LR, Grozio, A., Kubota, S., et al. (2016). Ntev-Lub Sijhawm Tswjhwm ntawm Nicotinamide Mononucleotide Mitigates Hnub nyoog-Txoj kev poob qis hauv cov nas. Cell Metabolism, 24(6), 795–806.

Cov ntsiab lus: Siv los txhawb cov ntaub ntawv ntawm cov qauv tsiaj. Txoj kev tshawb no pom tau hais tias ntev -NMN kev tswj hwm rau cov nas muaj hnub nyoog ua rau muaj peev xwm ua tau zoo dua qub thiab kev ua siab ntev, nrog rau cov ntaub ntawv uas feem ntau qhia tau hais tias cov nas laus (18 lub hlis) tswj hwm NMN tuaj yeem khiav mus txog 56% deb ntawm lub treadmill piv rau cov nas.

[3] Source: Yoshino, M., Yoshino, J., Kayser, BD, Patti, GJ, Franczyk, MP, et al. (2021). Nicotinamide mononucleotide nce cov leeg nqaij insulin rhiab heev rau cov poj niam prediabetic. Science, 372(6545), 1017-1021.

Cov ntsiab lus: Siv los txhawb cov tib neeg kev sim tshuaj ntsuam xyuas cov txiaj ntsig tsom rau kev noj qab haus huv metabolic. Qhov kev ntsuas no tau txheeb xyuas, tswj kev sim pom tias 250 mg ntawm NMN ib hnub rau 10 lub lis piam ua rau muaj kev nce siab hauv cov leeg nqaij insulin hauv cov poj niam rog rog lossis rog rog tom qab cov poj niam uas muaj ntshav qab zib. Kev txhim kho ntawm insulin rhiab heev tau tshaj tawm tias zoo ib yam li qhov pom tom qab tib neeg poob li 10% ntawm lawv lub cev hnyav.

[4] Source: Igarashi, M., Katagiri, M., Yamada, S., Ishikawa, T., Itoh, K., et al. (2022). Cov teebmeem ntawm 12 lub lis piam tau txais Nicotinamide Mononucleotide (NMN) ntawm cov leeg nqaij, qib NMN, thiab kev nyab xeeb rau cov poj niam laus noj qab haus huv. NPJ Aging, 8(1).

Cov ntsiab lus: Siv raws li kev siv ntxiv rau tib neeg kev sim siab, qhia txog kev ua haujlwm ntawm lub cev. Qhov kev sim no pom tias NMN noj rau 12 lub lis piam txhim kho cov leeg nqaij thiab taug kev ceev hauv cov poj niam laus noj qab haus huv, txhawb nqa cov txiaj ntsig ua haujlwm tshaj li cov cim metabolic.

[5] Tau qhov twg los: Kev Tshawb Fawb Kev Lag Luam, QYResearch Group, Lucintel (Ntau Daim Ntawv Qhia Tshaj Tawm 2024).

Cov ntsiab lus: Siv los txhawb cov ntaub ntawv lag luam. Lub ntiaj teb Nicotinamide Mononucleotide (NMN) kev lag luam loj muaj nqis kwv yees li ntawm USD $ 210 txog $ 360 lab hauv xyoo 2024 thiab tau kwv yees tias yuav loj hlob ntxiv, nrog rau ntau cov ntawv tshaj tawm uas muaj npe tau kwv yees qhov Compound Annual Growth Rate (CAGR) txij li 7.9% mus rau ntau dua 10% / 20} tsav los ntawm 20. thiab tiv thaiv kev noj qab haus huv tiam sis.