Nyob rau hauv xyoo tas los no, cov khoom zoo kawg nkaus tau coj lub ntiaj teb kev kawm los ntawm cua daj cua dub, qhuas tias yog ib qho kev cog lus zoo tshaj plaws los tiv thaiv kev laus ntawm lub xyoo pua. Qhov sib xyaw muaj zog no, Alpha-Ketoglutaric Acid (AKG), tuaj yeem yog riam phom zais cia koj xav tau kom ntev koj txoj kev noj qab haus huv thiab kev ua neej.
Tab sis ua li cas AKG pawg tawm tsam lwm cov tshuaj tiv thaiv kev laus xws li PQQ, NAD +, thiab NMN? Thiab yog vim li cas nws thiaj li ua rau muaj kev ntxhov siab nyob rau sab hnub poob? Cia peb tshawb nrhiav cov txiaj ntsig tshwj xeeb thiab kev tshawb fawb tom qab AKG.
Kev Tshawb Fawb Tom Qab AKG
AKG (-Ketoglutaric Acid)
Natural Production: Yog, nyob rau hauv tib neeg lub cev
Lub luag haujlwm tseem ceeb:
- Stimulates zog ntau lawm
- Synthesizes tseem ceeb proteins
- Txhim kho mitochondrial muaj nuj nqi
- Boosts kho cellular
Unique Mechanism: Activates TET proteins rau DNA demethylation, tseem ceeb heev rau qhov tseeb gene qhia
Sib piv nrog lwm cov tshuaj tiv thaiv kev laus
| Compound | Ntuj qhov chaw | Mechanism ntawm Action | Cov txiaj ntsig tseem ceeb | Kev tshawb fawb tseem ceeb |
|---|---|---|---|---|
| AKG | Tsis muaj kev noj haus | Stimulates ATP ntau lawm, activates AMPK, TET proteins rau DNA demethylation | Ua kom muaj zog, txhim kho mitochondrial muaj nuj nqi, thim rov qab lub hnub nyoog physiological | 2021 txoj kev tshawb fawb pom tau tias 8- xyoo rov qab los ntawm lub hnub nyoog epigenetic |
| PQQ | Yog (ntau yam khoom noj) | Txhim kho mitochondrial biogenesis, antioxidant zog | Txhim kho qib zog, tiv thaiv oxidative kev nyuaj siab | Kev tshawb fawb txog kev txhawb nqa mitochondrial thiab cellular zog |
| NAD+ | Yog (qee yam khoom noj) | Extens telomere ntev, stabilizes gene qhia | Txhawb DNA kho, boosts cellular noj qab haus huv | Ntau yam kev tshawb fawb txog kev laus thiab kev kho cellular mechanisms |
| NMN | Yog (qee yam khoom noj) | Precursor rau NAD +, txhawb nqa kev ua haujlwm mitochondrial | Txhim kho lub zog metabolism, txhawb lub neej ntev | Kev sim tib neeg tsis tu ncua, tseem nyob rau theem II |
Vim li cas AKG thiaj li ua Ntshai
Qhov kev zoo siab nyob ib puag ncig AKG tau pib xyoo 2014 thaum txoj kev tshawb fawb tau luam tawm hauv Nature qhia nws lub peev xwm. Kev tshawb fawb pom tau tias AKG txuas ntxiv lub neej ntawm Caenorhabditis elegans los ntawm 50%, qhia cov lus cog tseg tseem ceeb hauv kev ua kom txoj hauv kev AMPK, txo qhov mob, thiab txhim kho kev tiv thaiv antioxidant.
Txawm li cas los xij, qhov tseeb kev tawg tuaj hauv 2021 nrog kev tshawb fawb los ntawm National University of Singapore. Txoj kev tshawb no pom tias tom qab xya lub hlis ntawm AKG supplementation, cov neeg koom nrog lub hnub nyoog epigenetic physiological hloov los ntawm kwv yees li yim xyoo. Qhov kev tshawb pom tsis tau pom dua no yog ua raws li cov cim qhia kev noj qab haus huv thiab ua kom pom AKG qhov cuam tshuam loj heev rau tib neeg kev laus.
Tshwj xeeb zoo ntawm AKG
Tsis zoo li PQQ thiab NAD +, uas muaj nyob rau hauv cov zaub mov ntuj, AKG tsis tuaj yeem tau los ntawm kev noj haus. Raws li peb lub cev muaj hnub nyoog, lub ntuj tsim ntawm AKG txo qis, ua ntxiv rau tib txoj kev siv tau los tswj nws qib. Qhov no distinguishes AKG raws li ib tug tshwj xeeb thiab tseem ceeb tivthaiv nyob rau hauv kev sib ntaus tawm tsam kev laus.
AKG sawv tawm tsis yog ib tus neeg sib tw xwb tab sis ua tus thawj coj hauv kev tshawb nrhiav rau cov tub ntxhais hluas ntev thiab muaj zog. Nws lub peev xwm los thim rov qab kev laus ntawm lub cev hauv tib neeg kev sim siab yog ib tshooj tshiab hauv kev tshawb fawb los tiv thaiv kev laus. Yog tias koj tab tom nrhiav txhim kho koj txoj kev noj qab haus huv, AKG tsuas yog qhov kev hloov pauv uas koj xav tau.