Apigenin yog cov nroj tsuag ntuj flavone pom nyob rau hauv ntau cov txiv hmab txiv ntoo thiab zaub xws li parsley, dos, txiv kab ntxwv, tshuaj yej, chamomile, nplej sprouts thiab ib co seasonings. Nyob rau hauv xyoo tas los no, apigenin tau txais koob meej nyob rau hauv daim ntawv ntxiv hmoov vim qhov kev tshawb fawb tshiab ntawm nws cov txiaj ntsig kev noj qab haus huv thoob plaws.
Raws li ib qho flavonoid antioxidant, apigenin tuaj yeem pab tiv thaiv cov hlwb los ntawm kev puas tsuaj txuas rau kab mob kev loj hlob. Anti-inflammatory, los tiv thaiv kev ntxhov siab kuj tau pom nyob rau hauv cov kev tshawb fawb preclinical. Txawm tias tseem xav tau kev tshawb fawb ntxiv, apigenin hmoovzoo nkaus li cog lus rau kev txhawb nqa tag nrho lub cev kev noj qab haus huv.
Cov txiaj ntsig kev noj qab haus huv muaj peev xwm ntawm Apigenin Powder
1 Antioxidant Properties
Apigenin tau pom tias ua raws li lub zog antioxidant. Antioxidants pab tiv thaiv oxidative kev puas tsuaj los ntawm cov dawb radicals thiab reactive molecules uas tuaj yeem cuam tshuam cov hlwb hauv lub sijhawm. Qee qhov kev tshawb fawb hauv kev tshawb fawb qhia tias apigenin yog ib qho muaj zog antioxidant dua li cov vitamin C lossis E. Nws zoo nkaus li ua kom muaj cov tshuaj tiv thaiv antioxidant hauv lub cev uas tswj kev tiv thaiv oxidative kev nyuaj siab.
Los ntawm kev txhawb nqa antioxidant raws li txoj cai, apigenin tuaj yeem pab tiv thaiv kev raug mob ntawm tes ua rau muaj hnub nyoog txog cov kab mob xws li mob, tiv thaiv kab mob thiab ua kom muaj kev laus sai. Tshwj xeeb, apigenin tau pom tias nce qib ntawm glutathione, superoxide dismutase, catalase thiab lwm yam endogenous antioxidants. Nws kuj tseem txhim kho cov vitamin C thiab E kev ua kom pom kev dawb radical scavenging.
Los ntawm cov txheej txheem tiv thaiv no, apigenin tuav cov lus cog tseg rau kev tiv thaiv thiab tswj cov kab mob, kab mob plawv, neurodegeneration, mob ntshav qab zib mellitus, frailty, tiv thaiv kab mob thiab kev laus ntxov ntawm cov ntaub so ntswg. Tib neeg cov kev sim no tseem txwv, tab sis kev tshawb fawb tsiaj pom tau tias apigenin counters biomarkers ntawm oxidative puas thaum khaws cov ntaub so ntswg thiab kev ua haujlwm hauv lub hlwb, cov hlab plawv thiab lwm qhov chaw tseem ceeb.
2 Anti-Inflammatory Effects
Cov kab mob ntev yog nyob ntawm cov hauv paus hniav ntawm cov kab mob ntev. Raws li tus neeg sawv cev tiv thaiv kab mob, apigenin zoo li thaiv cov tshuaj tiv thaiv kab mob xws li COX-2, 5-LOX, FLAP, NF-kB thiab cov dej ntws qis ntawm cov kab mob xws li nitric oxide synthase-2 (iNOS-2), interleukin 6 (IL-6) thiab qog necrosis factor alpha (TNF-a). Apigenin tseem inhibit vascular cell adhesion molecule-1 (VCAM{11}}) thiab intercellular adhesion molecule-1 (ICAM-1) koom nrog hauv inflammatory immune cell migration thiab activation.
Apigenin cov tshuaj tiv thaiv kab mob tuaj yeem pab txo cov mob xws li mob caj dab, autoimmunity, kab mob plawv thiab kev paub tsis meej. Cov kev tshawb fawb ua ntej tseem qhia tau tias apigenin tuaj yeem tiv thaiv cov tsos mob ntawm kev ua xua los ntawm inflammatory histamine tso tawm. Nws kuj tseem tuaj yeem tuav cov lus cog tseg raws li tus neeg sawv cev chemopreventive hauv qee cov kab mob uas mob ntev ua rau cov qog loj hlob.
Los ntawm kev sib xyaw ua ke ntawm COX, LOX thiab NF-kB txoj kev hloov pauv, apigenin tau sim txo qis cov cell infiltration, edema, cov ntaub so ntswg fibrosis thiab kev puas tsuaj thoob plaws ntau cov ntaub so ntswg thiab kab mob. Cov txiaj ntsig tshwj xeeb yog qhov tseem ceeb rau cov kab mob neurological, dermatological, gastrointestinal, pulmonary, cardiovascular thiab cov kab mob sib koom ua ke hauv cov tsiaj ua qauv. Raws li ib qho piv txwv tseem ceeb, collagen-induced mob caj dab mob hnyav heev tau attenuated los ntawm apigenin.
3 Neuroprotective Properties
Kev tshawb fawb tshiab qhia tiasapigenin hmoovtxhawb nqa lub hlwb noj qab haus huv thiab muaj cov zoo neuroprotective. Hauv kev tshawb fawb tsiaj, apigenin tiv thaiv cov qauv neuron thiab ua haujlwm thaum txhawb kev kawm thiab kev nco. Tshwj xeeb, apigenin tiv thaiv kev poob ntawm lub sijhawm ntev potentiation koom nrog hauv kev tsim kev nco, txo tau cov protein ntau hyperphosphorylation cuam tshuam nrog Alzheimer's kab mob, khaws cov ntshav hauv lub hlwb kev ruaj ntseg, ua rau cov ntshav ntws mus rau hauv hlwb thiab txhim kho antioxidant muaj peev xwm hauv lub hlwb.
Nws kuj tau pom tias tiv thaiv lub hlwb mob los ntawm tib COX, NF-kB thiab nitric oxide txoj kev hloov kho uas tiv thaiv lwm cov ntaub so ntswg. Qhov no yog qhov tseem ceeb vim hais tias mob neuroinflamation yog ib qho tseem ceeb ntawm tus tsav tsheb hauv qab ntawm cov kab mob neurodegenerative thiab kev txawj ntse poob. Tsis tas li ntawd, apigenin txo qis amyloid plaques pom hauv Alzheimer tus kab mob thaum tiv thaiv neuron synaptic plasticity thiab neurotransmitter muaj nuj nqi txawm tias muaj beta-amyloid toxicity.
Tshaj li cov teebmeem ntawm cov neurons lawv tus kheej, apigenin tau txais txiaj ntsig cuam tshuam rau glial hlwb hu ua astrocytes uas txhawb nqa cov metabolism hauv neuronal thiab kev ua haujlwm. Kev noj qab haus huv astrocyte muaj nuj nqi tswj hwm los ntawm apigenin yog qhov tseem ceeb rau kev tiv thaiv kev loj hlob ntawm kev paub tsis meej me ntsis mus rau tag nrho cov kab mob Alzheimer's.
Apigenin kuj txhawb GABA receptors koom nrog hauv kev xav, pw tsaug zog thiab so kom txaus. Qhov no tuaj yeem txhawb kev paub txog kev noj qab haus huv thiab kev noj qab haus huv cov lus teb. Cov kev tshawb fawb tsiaj kuj qhia tau hais tias cov lus teb zoo li antidepressant, tshwj xeeb tshaj yog thaum ua ke nrog cov tshuaj tiv thaiv NSAID. Yog li tej zaum yuav muaj daim ntawv thov kev mob hlwb ib yam nkaus.
Lwm cov txiaj ntsig muaj peev xwm
1 Digestive Health
Apigenin zoo nkaus li so cov ntaub so ntswg hauv plab. Kev tshawb fawb-tube tau pom tias nws txhim kho kev thauj mus los ntawm chloride ion los txhim kho cov leeg nqaij thiab lub sijhawm hloov hauv txoj hnyuv. Qhov no qhia tias kev noj tshuaj apigenin tuaj yeem pab txo qis cem quav, raws plab lossis teeb meem plab zom mov. Txawm li cas los xij, kev tshawb fawb soj ntsuam ntxiv tseem xav tau hauv tib neeg.
Apigenin tiv thaiv lub plab mucosa los ntawm cawv, kev ntxhov siab thiab tsis-steroid anti-inflammatory tshuaj (NSAID)-vim kev puas tsuaj hauv cov nas. Qhov no qhia tau hais tias gastroprotective cuam tshuam rau cov digestive insults. Anti-inflammatory, antioxidant thiab apoptosis-modulating kev ua ub no kho gastroprotection thiab ceev kho ntawm rwj.
plab hnyuv smooth nqaij so mediated los ntawmapigenin hmoovkuj tseem tuaj yeem yooj yim raws plab uas cuam tshuam rau cov kab mob hauv plab hnyuv, kab mob los yog tshuaj phiv. Apigenin nce plab hnyuv motility thiab quav dej cov ntsiab lus nyob rau hauv ib txwm thiab cem quav nas uas yuav txhais tau rau cem quav.
2 Daim tawv nqaij noj qab haus huv
Thaum siv rau ntawm daim tawv nqaij, cov kev tshawb fawb qhia tias apigenin tiv thaiv kev puas tsuaj los ntawm cov dawb radicals, UV hluav taws xob thiab ib puag ncig cov pa phem. Nws kuj zoo nkaus li txo cov cell proliferation txuas nrog psoriasis thiab txawm inhibit melanoma.
Cov txiaj ntsig ua ntej no qhia tias apigenin tuaj yeem muab kev kho mob rau cov tawv nqaij laus, thiab cov tawv nqaij inflammatory thaum siv tshuaj pleev. Cov koob tshuaj ntawm qhov ncauj kuj ua rau cov tawv nqaij kaw hauv cov nas thaum nce collagen deposition, angiogenesis thiab antioxidant tiv thaiv.
3 Pob txha thiab Kev Noj Qab Haus Huv
Cov pov thawj tshwm sim qhia txog apigenin lub peev xwm los tiv thaiv cov pob txha noj qab haus huv thiab tiv thaiv osteoarthritis. Apigenin txhawb kev sib txawv ntawm osteoblast thiab cov pob txha nodule tsim hauv vitro los txhawb cov pob txha tsim muaj peev xwm. Nws kuj txo cov kev qhia ntawm proteolytic enzymes thiab inflammatory cytokines koom nrog hauv pob txha mos degradation.
Nyob rau hauv luav nrog ACL rupture, intra-articular txhaj ntawm apigenin suppressed MMP induced pob txha mos kev puas tsuaj thiab synovial o los txo osteoarthritis kev loj hlob. Qhov no qhia tau hais tias siv tau rau kev kho mob osteoarthritis.
Thaum kawg, apigenin tuaj yeem pab kho pob txha zoo raws li kev txhim kho alkaline phosphatase kev ua haujlwm thiab collagen synthesis sau tseg hauv kab lis kev cai osteoblast. Nws zoo nkaus li txhawb cov xwm txheej hauv zos koom nrog hauv kev tsim cov pob txha.
4 Kev Cai Ntshav Qab Zib
Ntau qhov kev tshawb fawb pom tias apigenin pab tswj cov ntshav qab zib thiab insulin rhiab heev thaum tiv thaiv pancreatic beta cell muaj nuj nqi. Qhov no tuaj yeem muaj feem cuam tshuam rau kev tiv thaiv lossis tswj ntshav qab zib. Cov txheej txheem muaj xws li stimulating insulin receptors, nce qabzib thauj cov proteins, hloov cov enzymes koom nrog hauv cov piam thaj metabolism thiab txo qis pancreatic cell apoptosis.
Kev tshawb fawb ntxiv yog xav tau, tab sis kev tiv thaiv kab mob, tshuaj tua kab mob antioxidant thiab insulin txoj kev hloov kho ua rau apigenin cog lus rau cov teeb meem xws li insulin tsis kam, mob ntshav qab zib neuropathy thiab endothelial dysfunction cuam tshuam nrog ntshav qab zib.
5 Immune System Modulation
Cov tshuaj tiv thaiv kab mob tiv thaiv tau zoo nyob ntawm kev sib npaug pro thiab tiv thaiv kab mob. Raws li tau hais tseg thoob plaws cov txiaj ntsig zoo,apigenin hmoovtxaus siab cuam tshuam qhov kev sib npaug ntawm cov kab mob sib txawv hauv xeev uas tau tsav los ntawm kev tswj tsis tau qhov mob lossis kev tiv thaiv kab mob ntawm cov ntaub so ntswg noj qab haus huv.
Tsis tas li ntawd, qee qhov kev ua ncaj qha tuaj yeem txhawb kev tiv thaiv kab mob hauv cov xwm txheej ib txwm muaj lossis xaiv lub siab. Nyob rau hauv tib neeg leukocytes, apigenin nce ntuj killer cell cytotoxicity tawm tsam qog hlwb. Nws kuj txhawb nqa neutrophil microbicidal muaj peev xwm thiab macrophage phagocytosis los rhuav tshem cov kab mob hauv cov qauv kab lis kev cai ntawm tes.
Qee yam kev tiv thaiv kab mob kuj tseem tuaj yeem ua pov thawj muaj txiaj ntsig zoo rau kev tswj kev ua xua lossis kab mob autoimmune uas tau tsav los ntawm kev tiv thaiv kab mob ntau dhau. Lub laub thiab rub taw qhia qhov xav tau rau ib qho immunomodulator uas tuaj yeem ua ob-directionally fine-tune tshwj xeeb ntawm kev tiv thaiv kab mob. Apigenin muab qhov kev tswj hwm muaj peev xwm.
6 Qhov muag Health
Apigenin qhia txog kev tiv thaiv kev tiv thaiv hauv retinal pigment epithelial hlwb raug oxidant kev puas tsuaj, qhia txog cov txiaj ntsig antioxidant uas tuaj yeem tiv thaiv cov nqaij mos ntawm qhov muag. Nws kuj tau hloov kho qhov kev qhia ntawm cov yam ntxwv zoo li NF-kB txuas rau qhov muag qhuav, uveitis thiab lwm yam teeb meem ntawm qhov muag.
Nyob rau hauv vivo qauv ntawm laser choroidal neovascularization mimicking hnub nyoog ntsig txog macular degeneration, apigenin suppressed to, o thiab angiogenesis hauv cov ntaub so ntswg retinal. Qhov no qhia tau hais tias muaj peev xwm los tawm tsam qhov muag tsis pom kev cuam tshuam nrog kev raug mob oxidative lossis kev loj hlob ntawm vascular tsis xwm yeem.
7 Kev Noj Qab Nyob Zoo
Antioxidant thiab anti-inflammatory kev ua ub no kuj yuav ua rau kom muaj kev sib deev zoo. Apigenin tiv thaiv zes qe menyuam follicle cia nyob rau hauv ib tug chemotherapy qauv ntawm lub zes qe menyuam ntxov ntxov tsis ua hauj lwm. Nws kuj tseem khaws cia cov spermatogenesis uas feem ntau cuam tshuam los ntawm cov tshuaj lom insults thiab aging yam uas ua rau dawb radical tiam thiab o nyob rau hauv lub testes.
Los ntawm kev sib ntaus sib tua oxidative quab yuam thiab o, apigenin tuaj yeem tiv thaiv kev yug me nyuam rau cov poj niam thiab txiv neej feem. Kev tshawb fawb soj ntsuam ntxiv tseem xav tau txog kev cuam tshuam ncaj qha. Tab sis downstream antioxidant thiab anti-inflammatory kev pab cuam yuav pab txhawb kev noj qab haus huv fertility thiab tiv thaiv tej yam tsav tsheb ntawm kev laus laus.
8 Kev nyab xeeb thiab kev siv
Tsis muaj qhov tsim nyog tau txais txhua hnub rau apigenin.Bulk apigenin hmoovcov tshuaj ntxiv feem ntau muab 50-100 mg ntawm apigenin ib nrab-teaspoon noj. Kev tshawb fawb ntau tshaj qhov tshuaj ntxiv rau cov txiaj ntsig kev noj qab haus huv hauv tib neeg yog 20-50 mg txhua hnub. Cov koob tshuaj txog li 50 mg tau noj ob zaug ib hnub twg tau siv yam nyab xeeb hauv qee qhov kev tshawb fawb.
Ntawm cov koob tshuaj ntxiv, apigenin hmoov zoo li muaj kev nyab xeeb heev. Txawm li cas los xij, kev sim mus sij hawm ntev tseem tsis muaj. Vim nws cov kev cuam tshuam nrog GABA receptors, apigenin tuaj yeem ua rau qaug zog lossis ua rau muaj kev ntxhov siab ntau ntxiv hauv cov neeg raug mob. Nws yog qhov zoo tshaj kom pib qis ntawm 12.5-25 mg txhua hnub los ntsuas qhov ua siab ntev.
Apigenin hmoov yuav tsum tsis txhob siv rau cov menyuam yaus, cov poj niam cev xeeb tub lossis cov neeg noj cov tshuaj GABA yam tsis muaj kev saib xyuas kev kho mob vim tsis muaj cov ntaub ntawv kev nyab xeeb. Thaum feem ntau zam tau zoo, cov quav xoob, xeev siab lossis kiv taub hau tuaj yeem ua tau ntawm cov tshuaj ntau dua hauv qee tus neeg.
Raws li lub ntuj flavone, apigenin tuaj yeem cuam tshuam nrog qee cov tshuaj uas yog metabolized los ntawm cytochrome P450 enzymes lossis ua rau qaug zog. Piv txwv suav nrog cov tshuaj benzodiazepines zoo li diazepam, cov tshuaj tiv thaiv kab mob xws li cyclosporine thiab cov tshuaj plawv zoo li amiodarone. Nrog rau tus kws kho mob ua ntej sib txuas cov tshuaj apigenin nrog cov tshuaj uas tau hloov los ntawm daim siab enzymes kom tsis txhob muaj kev cuam tshuam.
Xaus
Apigenin tau txais kev txaus siab sai sai raws li kev kho mob thiab kev tiv thaiv ntuj tsim vim nws cov tshuaj tiv thaiv antioxidant, tiv thaiv kab mob thiab kev tiv thaiv kab mob hauv cov kab lis kev cai ntawm tes, tsiaj txhu thiab qee qhov kev tshawb fawb tib neeg thaum ntxov. Cov ntaub ntawv ntxiv xws li cov hmoov loj tuaj yeem txhawb nqa tag nrho lub cev kev noj qab haus huv, tiv thaiv cov kab mob ntev xws li mob thiab oxidative kev nyuaj siab, thaum pab kev paub, mus ob peb vas, pw tsaug zog thiab ntau dua.
Tau kawg, qhov kev sim loj ntawm tib neeg yog qhov tseem ceeb rau cov txiaj ntsig zoo thiab kev pom zoo rau cov xwm txheej sib txawv. Tab sis cov pov thawj tam sim no qhia tias apigenin feem ntau muaj kev nyab xeeb heev thiab qhia tau hais tias kev cog lus raws li kev siv tau, kev tiv thaiv kev cog qoob loo thiab kev kho mob ntxiv. Apigenin bioavailability tuaj yeem txhim kho los ntawm kev sib xyaw ua ke zoo ib yam.
Thaum apigenin tshwm sim nyob rau hauv ntau cov zaub mov cog, kom tau txais cov ntsiab lus txaus rau kev kho mob feem ntau yuav tsum tau noj ntau yam tsis muaj tseeb. Yog li supplementation expands qhov chaw kho mob. Zuag qhia tag nrho, ntau yam flavone no tau teeb tsa los ua kom muaj kev tshawb fawb ntxiv rau kev siv tau ntxiv thiab nthuav dav siv cov txiaj ntsig kev noj qab haus huv uas txuas ntxiv tawm los ntawm cov chaw kuaj mob thoob ntiaj teb.
Yog tias koj tab tom nrhiav rau tus neeg muag khoom txhim khu kev qha raulag luam wholesale Apigenin hmoov, saib tsis muaj ntxiv tshaj Botanical Cube Inc. Peb muaj 3 lub hauv paus tsim khoom thiab ua ntau txhiab tons ntawm cov khoom siv cog qoob loo txhua xyoo. Nruab nrog cov thev naus laus zis siab heev thiab ua tiav cov kab ntau lawm, peb tuaj yeem ua kom ruaj khov ntawm cov khoom.
Ntxiv mus, peb cov khoom siv dav dav suav nrog ntau dua 200 ntau yam ntawm cov nroj tsuag rho tawm, uas tau xa tawm mus rau 60% ntawm lub tebchaws thoob ntiaj teb. Qhov no qhia txog peb txoj kev cog lus los muab cov khoom lag luam zoo rau cov tshuaj ntsuab thoob ntiaj teb, cov zaub mov noj qab haus huv, khoom noj khoom haus, zaub mov thiab dej haus, tshuaj txhua hnub, thiab kev lag luam tshuaj pleev ib ce.
Botanical Cube Inc. tau koom nrog kev lag luam cog qoob loo ntau xyoo thiab yog koj tus neeg muag khoom txhim khu kev qha. Yog koj xav tauApigenin hmoov, tiv tauj peb ntawmsales@botanicalcube.comlos yog mus saib peb lub vev xaib kom paub ntau ntxiv txog peb cov khoom lag luam botanical.
Cov ntaub ntawv:
1. Salehi, B., Venditti, A., Sharifi-Rad, M., Kregiel, D., Sharifi-Rad, J., Durazzo, A., Lucarini, M., Santini, A., Souto, EB, Novellino, E. thiab Antolak, H., 2019. Kev kho muaj peev xwm ntawm apigenin. International Journal of Molecular Sciences, 20(6), p.1290.
2.Xu, H., Chen, K. thiab Li, X., 2019. Apigenin hauv kev kho kab mob: kev tiv thaiv kab mob thiab cov txheej txheem ntawm kev ua. Cell & bioscience, 9(1), pp. 1-17.