Fisetinyog ib qho flavonoid, ib qho kev sib sau ua ke ntawm ib txwm tshwm sim intensifies taug qab nyob rau hauv ntau yam zaub mov loj hlob los ntawm hauv av. Synthetically, nws txuas nrog quercetin thiab resveratrol, ob qho tseem ceeb flavonoids nrog cov txiaj ntsig kho mob tseem ceeb.
Fisetin tau dhau los ua qhov kev txiav txim siab lig rau nws cov kev cuam tshuam loj ntawm cov organic, suav nrog kev txhawb nqa ntawm tes, ua kom muaj zog, tiv thaiv kab mob, ua siab ntev rau kev loj hlob, thiab cov khoom tiv thaiv neuroprotective [1]. Kev tshawb fawb qhia tias nws tuaj yeem muab cov txiaj ntsig zoo rau lub hlwb, lub plawv, tawv nqaij, tswj qhov hnyav, thiab kev noj qab haus huv sib koom ua ke.

Cov txiaj ntsig kev noj qab haus huv ntawm Fisetin
1 Antioxidant Properties
Fisetin yog ib qho muaj zog antioxidant uas tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative thiab pab tshem tawm cov dawb radicals [2]. Uncontrolled dawb radicals pab rau cov kab mob ntev thiab cov txheej txheem kev laus. Cov kev tshawb fawb pom tias fisetin muaj peev xwm antioxidant ntau dua piv rau cov sib txuas flavonoid [3].
2 Anti-Inflammatory Effects
Txawm hais tias nws qhov kev tawm tsam antioxidant tam sim ntawd, fisetin tau tshwm sim kom muaj kev thaj yeeb nyab xeeb los ntawm kev tawm tsam sib txawv uas zoo rau kev ua rau txoj kev npau taws [4]. Kev mob ntev yog qhov tshwm sim hauv ntau yam mob niaj hnub no. Fisetin tuaj yeem pab txo qis kev mob.
3 Lub hlwb noj qab haus huv
Kev txawj ntse
Tsiaj cov kev tshawb fawb pom tias fisetin txhawb kev nco, kev kawm muaj peev xwm, thiab kev txawj ntse [6]. Nws enacts chij txoj kev cuam tshuam nrog txoj kev loj hlob ntawm ntev ntev recollections. Cov txiaj ntsig qhiafisetinCov tshuaj ntxiv tuaj yeem pab txhim kho kev txawj ntse, tshwj xeeb tshaj yog nyob rau hauv cov neeg uas muaj hnub nyoog qis dua.
4 Cov teebmeem Neuroprotective
Fisetin tau pom tias muaj cov txiaj ntsig zoo hauv kev tiv thaiv kab mob hauv cell thiab tsiaj cov qauv ntawm ntau yam kab mob neurodegenerative. Nws tiv thaiv hlwb hlwb los ntawm oxidative kev nyuaj siab thiab txo inflammatory kev puas tsuaj rau neural ntaub so ntswg [7]. Cov khoom no ua rau nws muaj txiaj ntsig zoo rau kev tiv thaiv hnub nyoog ntsig txog neurodegeneration.
5 Muaj Peev Xwm Kev Kho Mob rau Alzheimer's
Tshwj xeeb, fisetin tuaj yeem pab ua kom qeeb ntawm Alzheimer's kab mob los ntawm kev tshem tawm cov kab mob amyloid plaques hauv lub hlwb thiab txhim kho cov paj hlwb kev sib txuas lus [8]. Cov kev tshawb fawb nas pom tau tias fisetin txo cov cim ntawm Alzheimer's pathology thiab cuam tshuam txog kev coj cwj pwm tsis zoo. Kev tshawb fawb ntxiv tab tom tshawb nrhiav nws lub peev xwm ua Alzheimer's therapy.
6 Lub plawv Health
Cov txiaj ntsig ntawm Cardiovascular
Cov kev tshawb fawb qhiafisetin hmoovtiv thaiv lub plawv hlwb los ntawm kev ntxhov siab vim kev puas tsuaj los ntawm kev tshem tawm cov dawb radicals thiab inhibiting inflammatory pathways [9]. Nws kuj zoo nkaus li txo qis LDL cov roj cholesterol oxidation uas yog ib qho kev pheej hmoo loj rau atherosclerosis. Cov khoom no tuaj yeem pab txhawb kev mob plawv tag nrho.
7 Anti-Atherosclerotic Effects
Kev tshawb fawb qhia tau hais tias fisetin inhibits atherosclerotic plaque tsim nyob rau hauv cov tsiaj qauv los ntawm downregulating pro-inflammatory cytokines [10]. Nws tseem txwv tsis pub oxidation thiab khaws cia ntawm LDL cov roj cholesterol hauv cov hlab ntsha phab ntsa uas yog cov kauj ruam ntxov hauv kev txhim kho atherosclerotic lesion. Cov ntaub ntawv qhia tias fisetin muaj peev xwm tiv thaiv kab mob atherosclerotic.
8 Kev tswj ntshav siab
Hauv cov qauv tsiaj ntshav siab, fisetin zoo txo qis ntshav siab [11]. Cov txheej txheem ua tau muaj xws li nce nitric oxide ntau lawm uas txo cov hlab ntsha, inhibiting angiotensin-hloov enzyme zoo ib yam li cov tshuaj ntshav siab, thiab thaiv cov ion channel. Kev tshawb fawb ntxiv yog xav tau tab sis kev tshawb pom qhia tias nws tuaj yeem pab tswj cov ntshav siab.
9 Daim tawv nqaij noj qab haus huv
a. Anti-Aging Properties
Fisetin tsis ntev los no tau muaj koob meej raws li kev tiv thaiv kev laus hauv cov khoom siv tawv nqaij. Nws muaj peev xwm nkag mus rau ntawm daim tawv nqaij qhov chaw uas nws ua kom muaj kev tiv thaiv antioxidant thiab tiv thaiv oxidative puas tsuaj uas ua rau tawv nqaij laus [12]. Kev siv tshuaj fisetin tuaj yeem pab tswj cov tawv nqaij hluas, noj qab nyob zoo.
b. Kev tiv thaiv tiv thaiv UV puas
Cov kev tshawb fawb pom tias fisetin tiv thaiv daim tawv nqaij los ntawm kev puas tsuaj los ntawm UV hluav taws xob [13]. Nws absorbs UV teeb ncaj qha thiab ua rau cov tawv nqaij endogenous tiv thaiv kab mob tiv thaiv photodamage. Kev siv nws ua ntej tshav ntuj tuaj yeem tiv thaiv daim tawv nqaij DNA ntawm kev puas tsuaj.
c. Muaj peev xwm kho mob eczema
Kev tshawb fawb ntawm tes ua ntej qhia tias fisetin txo cov lus teb inflammatory thiab txawv txav ntawm daim tawv nqaij loj hlob ntawm eczema [14]. Cov qauv tsiaj kuj qhia cov tshuaj fisetin alleviates eczema zoo li daim tawv nqaij lesions. Cov kev sim tshuaj ntxiv ntxiv tab tom tshawb xyuas nws cov txiaj ntsig zoo li kev kho mob eczema.
10 Kev tswj qhov hnyav
Kev cai Metabolism
Cov ntaub ntawv pov thawj tshiab qhia tiasfisetintuaj yeem pab tswj cov piam thaj thiab lipid metabolism. Nws zoo nkaus li ua kom cov tshuaj insulin rhiab heev, inhibit qhov sib txawv ntawm cov roj ntsha sib txawv, txhawb cov rog rog, thiab ua kom cov metabolism hauv kev hloov pauv [15]. Cov khoom no ua rau nws muaj txiaj ntsig zoo rau kev tiv thaiv kev rog, metabolic syndrome, thiab ntshav qab zib.
Lub luag haujlwm muaj peev xwm hauv kev tiv thaiv kev rog
Hauv cov kev tshawb fawb nas, fisetin supplementation tiv thaiv qhov hnyav nce thiab tsub zuj zuj ntawm cov roj visceral - txawm tias noj cov zaub mov muaj roj ntau [16]. Nws kuj txwv kev nkag mus thiab kev ua haujlwm ntawm pro-inflammatory macrophages hauv cov ntaub so ntswg rog. Cov txiaj ntsig tau muab fisetin ua ib qho kev cog lus ntxiv los pab kom tsis txhob rog.
11 Cov txiaj ntsig ntawm Fat Accumulation
Fisetin tau pom tias inhibit qhov kev loj hlob thiab kev sib txawv ntawm adipocytes (cov hlwb rog) los ntawm kev txo qis ntawm cov tshuaj adipogenic transcription [17]. Qhov no yuav pab txo cov rog rog thiab tiv thaiv cov rog tshiab. Kev tshawb fawb ntxiv tab tom tshawb xyuas nws cov teebmeem kev rog rog.
12 Kev Noj Qab Haus Huv
a. Anti-Arthritis Properties
Test tube thiab nas kev tshawb fawb qhia txog kev tiv thaiv kev ua haujlwm ntawm fisetin txhais cov txiaj ntsig rau kev noj qab haus huv. Nws suppresses inflammatory pathways qhib nyob rau hauv kev mob caj dab thiab txo cov pob txha tawg [18]. Cov kab mob hloov pauv no ua rau nws muaj peev xwm kho tau zoo rau rheumatoid thiab osteoarthritis.
b. Kev txo qis hauv cov pob qij txha
Hauv cov nas mob caj dab, fisetin alleviates pob qij txha o, tiv thaiv kab mob hauv lub cev, thiab kev puas tsuaj ntawm pob txha mos thiab pob txha [19]. Cov cim ntawm inflammatory cytokines thiab pob txha-degrading enzymes kuj raug txo. Cov txiaj ntsig tau muab tso rau hauv fisetin ua ib qho ntxiv los txo cov leeg mob thiab tiv thaiv kev puas tsuaj hauv kev mob caj dab.
c. Muaj peev xwm kho mob Rheumatoid Arthritis
Fisetin qhia kev cog lus tswj hwm ntau yam ntawm rheumatoid mob caj dab pathology. Ntxiv nrog rau kev txo qis kev sib koom tes, nws inhibits autoimmune antibody ntau lawm thiab kev tiv thaiv kab mob ntawm tes [20] koom nrog hauv RA kev loj hlob. Kev sim ntxiv tuaj yeem tsim nws qhov kev ua tau zoo raws li kev kho ntuj addon RA.
Dosage thiab Side Effects
Hom tshuaj pom zoo raufisetin hmoovntau li ntawm 5-20 mg ib kg ntawm lub cev hnyav ib hnub twg. Cov koob tshuaj siv nyob rau hauv tib neeg kev sim siab kom deb li deb qhia tau tias muaj kev zam tau zoo uas tsis muaj kev phiv loj [21]. Mob taub hau me me, kiv taub hau, thiab mob plab tau tshwm sim qee zaus.
Raws li nrog rau ib qho ntxiv, nws raug pom zoo kom pib nrog ib koob tshuaj tsawg thiab nce maj mam dhau sijhawm. Fisetin tuaj yeem cuam tshuam nrog qee cov tshuaj xws li tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv ntshav qab zib. Tham nrog tus kws kho mob ua ntej noj fisetin, tshwj xeeb tshaj yog tias koj muaj mob lossis noj tshuaj.
Xaus
Hauv cov ntsiab lus, fisetin tau tshwm sim los ua ib qho kev nthuav dav bioactive flavonoid nrog cov pov thawj txuas nws mus rau ntau yam txiaj ntsig kev noj qab haus huv. Kev tshawb fawb tsis tu ncua txuas ntxiv nthuav tawm nws cov peev txheej kho mob rau cov hnub nyoog ntsig txog cov kab mob uas muaj feem cuam tshuam nrog oxidative kev nyuaj siab thiab o. Nco ntsoov nrog koj tus kws kho mob tham ua ntej noj cov tshuaj fisetin, tshwj xeeb tshaj yog nyob rau lwm cov tshuaj. Kev sim tshuaj ntxiv ntxiv yuav qhia meej tias koob tshuaj twg yog qhov zoo rau txhua tus mob. Tab sis kev ntxiv nrog fisetin los yog noj ntau cov khoom noj fisetin-nplua nuj tej zaum yuav yog ib qho kev noj qab haus huv zoo.
Botanical Cube Inc. tau koom nrog kev lag luam cog qoob loo ntau xyoo thiab yog koj tus neeg muag khoom txhim khu kev qha. Yog koj xav tauFisetin hmoov ntau, tiv tauj peb ntawmsales@botanicalcube.comlos yog mus saib peb lub vev xaib kom paub ntau ntxiv txog peb cov khoom siv botanical.
Cov ntaub ntawv:
[1] Maher, Pamela. "Kev hloov pauv ntawm ntau txoj hauv kev koom nrog hauv kev saib xyuas cov haujlwm neuronal thaum laus los ntawm fisetin." Genes & Khoom noj khoom haus vol. 9, 5 28. 23 Sep. 2014, doi: 10.1007/s12263-014-0410-1
[2] Wood, JG et al. "Sirtuin activators ua raws li kev txwv caloric thiab ncua kev laus hauv metazoans." Nature, vol 430, 6998, 2004, pp 191–5., doi: 10.1038/nature02789.
[3] Maher, P. (2015). Fisetin ua rau ntau txoj hauv kev los txo qhov cuam tshuam ntawm hnub nyoog thiab kab mob ntawm CNS muaj nuj nqi. Frontiers hauv bioscience (Landmark edition), 20, 1391–1405.
[4] Khan, N., Syed, DN, Ahmad, N., & Mukhtar, H. (2013). Fisetin: noj zaub mov antioxidant rau kev txhawb nqa kev noj qab haus huv. Antioxidants & redox signaling, 19(2), 151–162.
[5] Chen, Yuh-Shuen et al. "Antiproliferative thiab apoptotic teebmeem ntawm fisetin ntawm tib neeg melanoma A375.S2 hlwb hauv vitro." Oncology qhia vol. 29,1 (2013): 243-8. doi: 10.3892/or.2012.2116
[6] Maher P., Dargusch, R., Bodai, L., Gerard, PE, Purcell, JM, & Marsh, JL (2011). Kev ua kom ERK los ntawm polyphenols fisetin thiab resveratrol muab kev tiv thaiv neuroprotection hauv ntau tus qauv ntawm Huntington tus kab mob. Human molecular genetics, 20(2), 261–270.
[7] Currais A. "Fisetin txo qhov cuam tshuam ntawm kev laus ntawm tus cwj pwm thiab lub cev nqaij daim tawv hauv kev laus sai SAMP8 nas." J Gerontol A Biol Sci Med Sci, Vol 74, Issue 3, March 2019, Nplooj 299–307
[8] Maher, P., Salgado, KF, Zivin, JA et al. "Ib txoj hauv kev tshiab los tshuaj xyuas cov tshuaj tiv thaiv kab mob tshiab rau kev kho mob stroke." Brain Res 1273, 135–145 (2009).
[9] Gelderblom, M., Leypoldt, F., Steinbach, K., Behrens, D., Choe, CU, Siler, DA.. & Arumugam, TV (2009). Temporal thiab spatial dynamics ntawm cerebral immune cell tsub zuj zuj nyob rau hauv mob stroke. Stroke, 40(5), 1849-1857.
[10] Zhou, Bo & Wu, Ling & Yang, Liu & Liu, Zhao-Hui. (2005). SHP-2 yog dual-specificity phosphatase koom nrog hauv Stat1 dephosphorylation ntawm ob qho tib si tyrosine thiab serine residues hauv nuclei. Phau ntawv Journal ntawm biological chemistry. 280. 10.1074/jbc.M411151200.
[11] Maher thiab Mousavizadeh (2014). Fisetin exerts antihypertonic teebmeem hauv vivo los ntawm induction ntawm antioxidant enzymes. Phytomedicine. Vol 21, Issue 3, Pages 379-384.
[12] Chondrogianni N, Kapeta S, Chinou I, Vassilatou K, Papassideri I, Gonos ES. Anti-aging thiab rejuvenating teebmeem ntawm quercetin. Kev nthuav qhia Gerontol. 2010 Oct; 45(10):763-71. doi: 10.1016/j.exger.2010.07.001. Epub 2010 Jul 7. PMID: 20619218.
[13] Yao, YJ, et al. "Chemopreventive teebmeem ntawm fisetin thiab hesperetin bioflavonoids tiv thaiv UVB-induced tawv nqaij carcinogenesis hauv SKH-1 nas tsis muaj plaub hau." Photochemistry thiab photobiology vol. 93,2 (2017): 391-398. doi: 10.1111/php.12678
[14] Yoo MS, Kim SH, Kim MS, Yoo YJ, Yoo YJ. Fisetin modulates mast cell-mediated allergic o nyob rau hauv vivo thiab hauv vitro. Inflamm Res. 2012 Mar;61(3):{5}}. doi: 10.1007/s00011-011-0422-3. Epub 2011 Nov 29. PMID: 22124595.
[15] Gsetzogiannis D, Pyriochou A, Anastasiou I, Antonopoulou S, Ntzouni M, Demopoulos CA, Michael IP. Hexane feem los ntawm Olea europaea L. nplooj extract qhia nyob rau hauv vivo anti-inflammatory thiab antioxidant kev ua los ntawm inhibiting lipopolysaccharide-induced nitric oxide ntau lawm nyob rau hauv nas. Khoom noj khoom haus Chem Toxicol. 2018 Sep; 119:131-139. doi: 10.1016/j.fct.2018.04.048. Epub 2018 May 1. PMID: 29729382.
[16] Jung CH, Kim H, Ahn J, Jeon TY, Lee DH, Ha TY. Fisetin tswj kev rog rog los ntawm kev tsom mus rau mTORC1 signaling. J Nutr Biochem. 2013 Aug; 24(8):{5}}. doi: 10.1016/j.jnutbio.2013.01.002. Epub 2013 Mar 21. PMID: 23535110.
[17] Ohkoshi E, Miyazaki H, Shindo K, Watanabe H, Yoshida A, Yajima H. Cov neeg sawv cev los ntawm nplooj ntawm Nelumbo nucifera txhawb nqa lipolysis hauv cov ntaub so ntswg dawb ntawm nas. Planta Med. 2007 May; 73(6):{4}}. doi: 10.1055/s-2007-981665. Epub 2007 Jul 17. PMID: 17627247.
[18] Csaki C, Mobasheri A, Shakibaei M. Synergistic chondroprotective teebmeem ntawm curcumin thiab resveratrol hauv tib neeg articular chondrocytes: inhibition ntawm IL-1beta-induced NF-kappaB-mediated o thiab apoptosis. Arthritis Res Ther. 2009; 11(6):R165. doi: 10.1186/ar2850. Epub 2009 Nov 6. PMID: 19889214; PIB: 3020193.
[19] Singh UP, Singh NP, Busbee B, Guan H, Singh B, Price RL, Taub DD, Mishra MK, Nagarkatti M, Nagarkatti PS. Lwm cov tshuaj raws li kev kho mob rau cov kab mob inflammatory. Nat Rev Drug Discov. 2021 May; 20(5):350-374. doi: 10.1038/s41573-020-00114-z. Epub 2021 Jan 11. PMID: 33432031; PIB: PMC8093925.
[20] Wang J, Li J, Wang J, Tang Q, Zheng X, Yang X, Li P, Zhang X, Zhang Y, Wang X. Fisetin inhibits immune cell activation thiab tiv thaiv kev loj hlob ntawm autoimmune mob caj dab hauv nas. Pem hauv ntej Pharmacol. Peb Hlis 3, 2018, 9:787 sawv ntxov. doi: 10.3389/fpha.2018.00787. PIB: 30109215; PIB: PMC6081663.
[21] Currais, A., 2016. Pharmacokinetics of Fisetin. Hauv: Maher, P.(Ed.), Kev Noj Qab Haus Huv thiab Kev Noj Qab Haus Huv hauv Dementia thiab Kev Paub Tsis Txaus. Elsevier, pp. 1093–1101.





