Honokiol yog lub ntuj tsim tau los ntawm cov tawv ntoo, cov noob cones, thiab nplooj ntawm cov ntoo uas muaj npe rau Magnolia genus, tshwj xeeb tshaj yog Magnolia officinalis.Honokiol Extractmuaj keeb kwm ntev ntawm kev siv hauv cov tshuaj Esxias cov tshuaj siv los kho ntau yam mob. Nyob rau hauv xyoo tas los no, niaj hnub kev tshawb fawb tshawb fawb tau pib nthuav tawm cov txheej txheem tom qab honokiol cov txiaj ntsig kev noj qab haus huv, ua rau muaj kev txaus siab rau honokiol ua tus neeg sawv cev kho mob. Kab lus no muab cov ntsiab lus ntawm honokiol, nws yuav muab rho tawm li cas, nws siv, kev xav txog kev nyab xeeb, thiab kev tshawb fawb pheej hmoo ntawm nws cov khoom siv tshuaj.
Honokiol yog cais raws li lignan, uas yog ib chav kawm ntawm polyphenol cog metabolites. Nrog rau nws cov isomer magnolol, honokiol zoo nkaus li yog ib qho tseem ceeb bioactive tivthaiv ntawm Magnolia officinalis (houpo magnolia) bark extracts siv nyob rau hauv tsoos suav tshuaj. Houpo magnolia bark npaj tau raug sau tseg rau ntau pua xyoo los kho ntau yam kev tsis txaus siab ntawm plab hnyuv, ntxhov siab, mob stroke, thiab lwm yam mob. Cov kws tshawb fawb tau ntaus nqi ntau yam kev kho mob ntawm magnolia bark extracts rau lub xub ntiag ntawm honokiol thiab magnolol lignans.
Kev nkag siab txog kev rho tawm, siv, thiab cov txiaj ntsig tshuaj ntawm cov khoom siv ntuj xws li honokiol yog qhov tseem ceeb thaum peb tseem tshawb nrhiav thiab siv tau cov tshuaj cog qoob loo. Honokiol qhia txog kev cog lus tshwj xeeb vim nws muaj zog antioxidant, tiv thaiv kev mob, anxiolytic, thiab neuroprotective zog pom tau hais tias hauv cellular thiab tsiaj kev tshawb fawb. Raws li kev tshawb fawb ntawm honokiol txuas ntxiv mus, nws yuav muaj kev nyab xeeb dua thiab muaj txiaj ntsig zoo rau kev tswj hwm qee yam mob.
Honokiol yog dab tsi?
Honokiol yog biphenolic compound nrog cov mis mos molecular C18H18O2. Nws lub npe IUPAC yog 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol. Honokiol muaj qhov hnyav molecular ntawm 266.33 g / mol thiab zoo li cov hmoov dawb crystalline hauv nws daim ntawv ntshiab. Nws yog lipid soluble thiab tshuaj lom neeg ruaj khov.
Nrog rau magnolol, honokiol yog suav hais tias yog ib qho ntawm cov khoom tseem ceeb bioactive tau muab rho tawm los ntawm cov tawv ntoo, cov noob cones, thiab nplooj ntawm Magnolia officinalis thiab lwm yam Magnolia hom xws li Magnolia obovata thiab Magnolia grandiflora. Honokiol cov ntsiab lus tuaj yeem sib txawv heev nyob ntawm seb hom nroj tsuag, ib feem, thaj tsam cog qoob loo, thiab txoj kev rho tawm. Feem ntau, M. officinalis bark muaj ntau dua ntawm honokiol piv rau nplooj thiab paj.
Honokiol tau siv nyob rau hauv tsoos suav, Japanese, thiab Korean tshuaj rau ntau pua xyoo. Kev siv ib txwm muaj xws li kho kev ntxhov siab, cov tsos mob plab, mob stroke, thiab lwm yam. Kev tshawb fawb niaj hnub tam sim no yog tsom rau honokiol's antioxidant, anti-inflammatory, anxiolytic, antitumor, thiab neuroprotective zog pom nyob rau hauv cov kev tshawb fawb preclinical.
Cov txiaj ntsig kev noj qab haus huv ntawm Honokiol Extract
Lub cev loj hlob ntawm kab lis kev cai ntawm tes thiab kev tshawb fawb tsiaj qhia tias honokiol muaj cov tshuaj muaj zog uas yuav pab tau rau kev tswj lossis tiv thaiv ntau yam mob. Qee yam ntawm honokiol cov txiaj ntsig tshuaj muaj txiaj ntsig tau txhawb los ntawm kev tshawb fawb tshawb fawb suav nrog:
- Cov teebmeem anxiolytic: Honokiol zoo li ua rau GABA receptors hauv lub hlwb zoo ib yam li cov tshuaj benzodiazepine siv los kho kev ntxhov siab. Cov kev tshawb fawb tsiaj pom tias honokiol ua rau muaj kev ntxhov siab vim tsis muaj kev phiv tshuaj sedative.
- Neuroprotective zog: Honokiol qhia muaj zog antioxidant thiab anti-inflammatory zog nyob rau hauv lub hlwb. Cell thiab tsiaj cov kev tshawb fawb qhia tias nws yuav pab tiv thaiv neurons thiab txo cov neuronal puas nyob rau hauv tej yam mob xws li mob stroke, Parkinson tus kab mob, thiab Alzheimer's kab mob.
- Cov khoom siv tshuaj tua kab mob: Honokiol qhia cov kab mob tua kab mob thiab tshuaj tua kab mob hauv vitro thiab qhia txog kev tiv thaiv kab mob microbial hauv cov qauv tsiaj. Qhov no suav nrog kev ua haujlwm tiv thaiv kab mob tiv thaiv kab mob xws li MRSA.
- Cov teebmeem inflammatory: Honokiol inhibits inflammatory mediators koom nrog cov kab mob xws li mob caj dab, colitis, thiab neuroinflammation. Nws tuaj yeem pab txo cov mob uas tsis muaj kev phiv ntawm NSAIDs thiab corticosteroids.
- Cov pob txha kho pob txha: Hauv vitro thiab nas kev tshawb fawb qhia tias honokiol tuaj yeem txhawb kev tsim cov pob txha thiab tej zaum yuav muaj txiaj ntsig zoo rau kev tswj cov pob txha thiab txhawb kev kho pob txha.
Thaum cog lus, feem ntau cov kev tshawb fawb ntawm honokiol txoj kev kho muaj peev xwm tseem nyob hauv theem ua ntej. Ntau cov tshuaj pharmacokinetic, kev nyab xeeb, thiab tib neeg cov kev tshawb fawb soj ntsuam tseem xav tau ua ntej honokiol extract tuaj yeem pom zoo rau feem ntau siv tshuaj.
Extraction Methods rau Honokiol
Honokiol feem ntau yog muab rho tawm los ntawm cov tawv ntoo los yog cag ntoo ntawm Magnolia officinalis, Magnolia obovata, thiab lwm yam Magnolia hom. Ntau yam txuj ci tuaj yeem siv los rho tawm thiab cais cov honokiol los ntawm cov khoom cog, nrog rau feem ntau:
- Cov kuab tshuaj rho tawm - Siv cov kuab tshuaj xws li cawv, ethyl acetate, lossis acetone los rho tawm honokiol thiab magnolol los ntawm magnolia bark.
- Supercritical kua extraction (SFE) - Siv supercritical CO2 tov nrog ib tug co-solvent los xaiv extract honokiol. Pom tau zoo dua li cov kuab tshuaj rho tawm.
- Microwave-pab extraction (MAE) - Siv lub zog microwave thiab cov kuab tshuaj kom sai sai tshem tawm honokiol los ntawm magnolia bark. Tej zaum yuav txhim khu kev extraction efficiency.
- Ultrasonic-pab extraction - Siv ultrasonic tsis thaum lub sij hawm hnyav extraction uas txhim kho extraction tawm los thiab txo lub sij hawm.
Lwm txoj hauv kev xws li kab chromatography, npaj HPLC, los yog high-ceev countercurrent chromatography yog siv los ntxiv cais thiab purify honokiol los ntawm crude cog rho tawm. Cov yam ntxwv zoo li cov txheej txheem rho tawm, hom hnyav, qhov kub thiab txias / siab, thiab cov nroj tsuag qhov cuam tshuam honokiol cov ntsiab lus thiab purity.
1 Txheej Txheem Extraction
Cov kuab tshuaj rho tawm yog ib txoj hauv kev zoo tshaj plaws thiab siv tau rau kev rho tawm honokiol los ntawm magnolia bark hauv qhov chaw kuaj. Nws koom nrog kev siv cov kuab tshuaj organic los xaiv kom rho tawm qhov xav tau honokiol tebchaw los ntawm cov khoom cog. Nov yog cov ntsiab lus ntawm cov kuab tshuaj extracting honokiol:
Khoom siv
- Qhuav magnolia officinalis bark los yog cag ntoo
- Organic extraction kuab tshuaj xws li ethanol, methanol, acetone, ethyl acetate
- Lim ntawv, khob iav, nplawm apparatus, rotary evaporator
Txheej txheem
1. Siv cov tawv ntoo magnolia qhuav thiab zom rau hauv cov hmoov coarse.
2. Ntsuas qhov muaj pes tsawg leeg ntawm cov hmoov nplej thiab muab tso rau hauv lub khob nrog cov kuab tshuaj uas tau xaiv xws li 95% ethanol.
3. Siv cov kuab tshuaj tshwj xeeb rau cov qauv piv txwv thiab do cov sib tov rau lub sijhawm teev tseg ntawm chav tsev kub lossis nrog cua sov.
4. Lim cov sib tov los ntawm cov ntawv lim kom cais cov kuab tshuaj extract los ntawm cov khoom tawv tawv.
5. Muab cov kuab tshuaj rho tawm nyob rau hauv lub tshuab nqus tsev siv lub tshuab rotary evaporator.
6. Rov ua cov txheej txheem rho tawm ntau zaus, sib txuas cov kev daws teeb meem.
7. Purify lub consolidated extract tov siv cov tswv yim xws li kua-kua extraction los yog kem chromatography.
8. Txheeb xyuas qhov kawg honokiol extract qauv siv txoj kev zoo li HPLC los txiav txim siab purity thiab muaj pes tsawg leeg.
Cov ntsiab lus tseem ceeb uas cuam tshuam rau kev siv cov kuab tshuaj organic xws li hnyav polarity, pH, kub, lub sij hawm rho tawm, piv txwv, thiab particle loj. Yuav tsum tau ceev faj txog kev nyab xeeb kom raug thaum siv cov kuab tshuaj flammable.
2 Supercritical Fluid Extraction Method
Supercritical fluid extraction (SFE) siv cov kua supercritical zoo li supercritical CO2 kom rho tawm cov hom phiaj sib txuas los ntawm cov khoom cog. SFE yog suav tias yog ntau npaum thiab xaiv rau extracting honokiol piv rau cov pa organic hnyav extraction. Nov yog cov ntsiab lus ntawm supercritically extracting honokiol:
Khoom siv
- Supercritical kua extraction system
- Compressed CO2 thiab co-solvent zoo li ethanol
- Magnolia officinalis bark los yog hauv paus bark hmoov
- Extract sau vials
Txheej txheem
1. Muab magnolia bark hmoov rau hauv lub nkoj extraction hauv SFE system.
2. Teem kub thiab siab tej yam kev mob kom ua tau supercritical CO2 .
3. Cia supercritical CO2 dhau los ntawm cov qauv kom rho tawm honokiol.
4. Rau kev rho tawm tau zoo dua, ntxiv cov kuab tshuaj xws li ethanol rau CO2.
5. Sau cov rho tawm honokiol feem nyob rau hauv lub sau vials.
6. Rov ua cov txheej txheem rho tawm kom txog thaum honokiol tau muab tshem tawm tag nrho ntawm cov khoom siv tawv ntoo.
7. Txheeb xyuas cov honokiol extract muaj pes tsawg leeg siv HPLC lossis lwm txoj hauv kev.
SFE tso cai rau kev tswj hwm qhov kub thiab txias, siab, sib xyaw ua kua sib piv, thiab lwm yam tsis zoo los xaiv cov hom phiaj sib xyaw xws li honokiol thaum tshem tawm cov khoom tsis xav tau. Qhov no tuaj yeem ua rau lub siab ntshiab honokiol extract hauv lub sijhawm luv luv dua piv rau cov kuab tshuaj rho tawm. Cov kev txwv tseem ceeb yog cov nqi khoom siv siab.
3 Lwm qhov chaw thiab kev txiav txim siab
Thaum Magnolia officinalis yog qhov ntau tshaj plaws, honokiol kuj tuaj yeem muab rho tawm los ntawm lwm hom magnolia xws li Magnolia obovata, Magnolia grandiflora, Magnolia tripetala, thiab Magnolia hypoleuca. Cov ntsiab lus honokiol tuaj yeem sib txawv raws li hom magnolia, cov khoom siv cog, thaj chaw, thiab cov txheej txheem rho tawm.
Thaum xaiv ib qho honokiol extract, cov kev xav tseem ceeb suav nrog:
- Purity - Lub hom phiaj rau cov txheej txheem rho tawm tau lees tias muaj qee feem pua ntawm honokiol. Kev sim siv HPLC tuaj yeem txheeb xyuas qhov muaj pes tsawg leeg.
- Txoj kev Extraction - Supercritical CO2 extraction yuav muab siab dua purity piv rau hnyav extraction.
- Nroj tsuag - M. officinalis bark feem ntau muaj ntau dua honokiol piv rau nplooj lossis paj.
- Kev sim thib peb - Cov tuam txhab muaj koob npe yuav tsum muab cov ntawv pov thawj kuaj kom muaj txiaj ntsig zoo ntawm cov extract purity thiab muaj pes tsawg leeg.
- Dosage form - Honokiol qhov ncauj tshuaj tuaj yeem ua cov ntawv zoo li hmoov, tshuaj ntsiav, ntsiav tshuaj, thiab tinctures.
Kev siv Honokiol Extract
Kev lig kev cai, magnolia bark npaj muaj honokiol tau siv hauv Suav tshuaj los kho ntau yam mob, suav nrog:
- Kev tsis txaus siab ntawm plab hnyuv xws li mob plab, ntuav, thiab raws plab
- hnoos thiab mob hawb pob
- Kev ntxhov siab, kev ntxhov siab, thiab kev ntxhov siab
- Mob stroke thiab neurological teeb meem
- Rheumatism thiab mob leeg
Hauv kev siv niaj hnub no, honokiol extracts qhia tau hais tias muaj peev xwm kho tau zoo rau:
- Tswj kev ntxhov siab me me thiab kev ntxhov siab
- Txhawb lub hlwb kev noj qab haus huv thiab neuroprotection
- Txo neuroinflamation
- Ua raws li cov tshuaj tua kab mob tiv thaiv kab mob tshuaj tiv thaiv kab mob
- Txhawb cov pob txha tsim thiab kho
- Tiv thaiv daim tawv nqaij los ntawm UV puas
Honokiol kuj tseem siv rau hauv cov tshuaj pleev ib ce thiab cov khoom tu tawv nqaij ua antioxidant thiab tiv thaiv kev laus. Kev tshawb fawb ntxiv tseem yuav tsum tau ua kom tiav qhov kev lees paub ntawm honokiol txoj kev kho mob thiab kev nyab xeeb rau ntau yam ntawm cov ntawv thov no hauv tib neeg.
Kev nyab xeeb thiab kev phiv
Raws li kev tshawb fawb tsiaj toxicity, honokiol zoo li muaj toxicity tsawg thiab muaj kev nyab xeeb siab. Tsis muaj qhov cuam tshuam loj heev tau raug tshaj tawm hauv tib neeg kev tshawb fawb siv magnolia bark extracts standardized rau honokiol. Cov teebmeem me me tuaj yeem suav nrog:
- Mob plab plab me ntsis
- Ua kom tsaug zog / sedation
- Txo cov ntshav siab
Qee qhov kev tshawb fawb preclinical tau siv cov koob tshuaj ntau heev ntawm honokiol, feem ntau intravenously, ua rau nws nyuaj rau kev tsim cov lus pom zoo rau tib neeg qhov ncauj. Feem ntau cov ntawv sau ntxiv qhia tias 50-500 mg noj 1-3 zaug hauv ib hnub. Vim tias tsis muaj tib neeg cov ntaub ntawv toxicity, FDA tsis tau tsim kom muaj Kev Tiv Thaiv Upper Limit (UL) rau honokiol kom tsawg.
Honokiol tuaj yeem cuam tshuam nrog cov tshuaj xws li:
- Sedatives
- Cov tshuaj antihypertensive
- Anticoagulant / antiplatelet cov neeg ua haujlwm
Leej twg noj cov tshuaj yuav tsum sab laj nrog lawv tus kws kho mob ua ntej siv cov tshuaj honokiol. Kev siv Honokiol yuav tsum zam thaum cev xeeb tub thiab pub niam mis vim tsis muaj cov ntaub ntawv kev nyab xeeb. Ntau tus tib neeg cov tshuaj pharmacokinetic, kev sib cuam tshuam tshuaj, thiab kev tshawb fawb soj ntsuam yuav tsum tau ua kom zoo dua rau kev soj ntsuam honokiol txoj kev ua tau zoo rau kev siv tshuaj thiab tsim kom muaj cov lus qhia meej npaum li cas.
Xaus
Honokiol yog ib qho kev cog lus phytochemical uas tau siv ib txwm siv rau ntau pua xyoo thiab tam sim no tau raug tshawb xyuas rau nws cov khoom siv kho mob ntau yam. Ntau kab lis kev cai ntawm tes thiab tsiaj tshawb fawb qhia tias honokiol yuav muaj zog antioxidant, tiv thaiv kab mob, neuroprotective, anxiolytic teebmeem. Honokiol yog muab rho tawm los ntawm magnolia bark thiab lwm yam nroj tsuag siv txoj kev xws li hnyav extraction thiab supercritical kua extraction. Nws qhia tau hais tias muaj peev xwm tswj hwm cov xwm txheej xws li kev ntxhov siab me me mus rau cov kab mob loj xws li Alzheimer's thaum siv cov koob tshuaj tsim nyog. Txawm li cas los xij, ntau cov kev tshawb fawb soj ntsuam hauv tib neeg yuav tsum tau ua kom pom tseeb cov tshuaj siv rau honokiol extracts. Nyob rau hauv lub neej yav tom ntej, honokiol tej zaum yuav muab ib tug zoo supplemental los yog botanical tshuaj xaiv rau tej yam mob. Tab sis rau tam sim no, kev ntxiv yuav tsum tsuas yog txiav txim siab nrog kev cob qhia kws kho mob tom qab kev ntsuam xyuas qhov txiaj ntsig zoo-kev pheej hmoo.
Botanical Cube Inc. yog tus kws tshaj lijHonokiol Extract Powder Chaw tsim tshuaj pausuas koj tso siab tau. Yog tias koj txaus siab rau cov khoom no lossis xav paub ntxiv, thov hu rau sales@botanicalcube.com. Lub tuam txhab tsom rau kev tsim kho tshiab, kev tshawb fawb thiab kev tsim kho, thiab kev ruaj ntseg zoo los muab cov neeg siv khoom nrog cov khoom xyaw zoo. Peb ua haujlwm nrog cov cuab yeej ntsuas siab thiab txheeb xyuas cov cuab yeej thiab koom tes nrog cov chaw soj nstuam thib peb kom muaj kev ruaj ntseg, kev nyab xeeb, thiab kev ua haujlwm ntawm lawv cov khoom.
Cov ntaub ntawv
1. Yang, SA, Paik, SK, Koo, JS, & Kim, HJ (2020). Honokiol: Ib tus neeg sib tw muaj peev xwm los kho cov kab mob neurological. Pharmacology & Therapeutics, 215, 107582.
2. Woodbury, A., Yu, SP, Wei, L., & García, P. (2013). Neuro-modulating teebmeem ntawm honokiol: kev tshuaj xyuas. Frontiers hauv neurology, 4, 130.
3. Chui, CH, Lau, FY, Chan, AS, Cheng, GY, Wong, RS, Lai, KB, ... & Wan, DC (2005). Honokiol induces apoptosis nyob rau hauv tib neeg ntau yam myeloma cell kab U266. Molecular Disease Therapeutics, 4(4), 577-585.
4. Hui, KM, Huen, MS, Wang, HY, Zheng, H., Sigel, E., Baur, R., ... & Xue, H. (2007). Cov nyhuv anxiolytic ntawm wogonin, benzodiazepine receptor ligand cais tawm ntawm Scutellaria baicalensis Georgi. Biochemical pharmacology, 74(8), 1415-1424.
5. Friedman, M. (2015). Chemistry, antioxidant thiab antimicrobial kev ua ub no ntawm honokiol thiab magnolol. Hauv Bioactive natural khoom rau kev siv tshuaj (pp. 117-133). Apple Academic Press.
6. Shen, YC, Chang, CK, Tien, JH, Yu, CS, Chen, CC, & Liu, SH (2018). Niaj hnub no txoj kev ntawm extraction ntawm honokiol los ntawm Magnolia officinalis. Molecules, 23(9), 2163.
7. Houbraken, J., Frisvad, JC, & Samson, RA (2020). Taxonomy ntawm Magnolia spp. thiab lwm yam tsiaj. IMA fungus, 11(1), 5.
8. Levis, Y., Amit, T., Mandel, S., & Youdim, MB (2003). Neuroprotection thiab neurorescue tiv thaiv Abeta toxicity thiab PKC-dependent tso tawm ntawm nonamyloidogenic soluble precursor protein los ntawm ntsuab tshuaj yej polyphenol (-)-epigallocatechin-3-gallate. FASEB journal, 17(8), 952-954.